Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Biological or biochemical
Reexamination Certificate
2006-03-21
2006-03-21
Moran, Marjorie A. (Department: 1631)
Data processing: measuring, calibrating, or testing
Measurement system in a specific environment
Biological or biochemical
C382S128000, C382S133000
Reexamination Certificate
active
07016787
ABSTRACT:
A method for generating stimulus response curves (e.g., dose response curves) shows how the phenotype of one or more cells change in response to varying levels of the stimulus. Each “point” on the curve represents quantitative phenotype for cell(s) at a particular level of stimulus (e.g., dose of a therapeutic). The quantitative phenotypes are multivariate phenotypic representations of the cell(s). They include various features of the cell(s) obtained by image analysis. Such features often include basic parameters obtained from images (e.g., cell shape, nucleus area, Golgi texture) and/or biological characterizations derived from the basic parameters (e.g., cell cycle state, mitotic index, etc.). The stimulus response curves may be compared to allow classification of stimuli and identify subtle differences in related stimuli. To facilitate the comparison, it may be desirable to present the response curves in a principal component space.
REFERENCES:
patent: 4818710 (1989-04-01), Sutherland et al.
patent: 4922092 (1990-05-01), Rushbrooke et al.
patent: 4959301 (1990-09-01), Weaver et al.
patent: 4965725 (1990-10-01), Rutenberg
patent: 5016283 (1991-05-01), Bacus et al.
patent: 5162990 (1992-11-01), Odeyale et al.
patent: RE34214 (1993-04-01), Carlsson et al.
patent: 5281517 (1994-01-01), Bacus et al.
patent: 5287272 (1994-02-01), Rutenberg et al.
patent: 5326691 (1994-07-01), Hozier
patent: 5355215 (1994-10-01), Schroeder et al.
patent: 5526258 (1996-06-01), Bacus
patent: 5548661 (1996-08-01), Price et al.
patent: 5655028 (1997-08-01), Soll
patent: 5710022 (1998-01-01), Zhu et al.
patent: 5733721 (1998-03-01), Hemstreet, III et al.
patent: 5741648 (1998-04-01), Hemstreet et al.
patent: 5768412 (1998-06-01), Mitsuyama et al.
patent: 5776748 (1998-07-01), Singhvi et al.
patent: 5777888 (1998-07-01), Rine et al.
patent: 5790692 (1998-08-01), Price et al.
patent: 5790710 (1998-08-01), Price et al.
patent: 5804436 (1998-09-01), Okun et al.
patent: 5856665 (1999-01-01), Price et al.
patent: 5893095 (1999-04-01), Jain et al.
patent: 5919646 (1999-07-01), Okun et al.
patent: 5932872 (1999-08-01), Price
patent: 5962520 (1999-10-01), Smith et al.
patent: 5976825 (1999-11-01), Hochman
patent: 5985549 (1999-11-01), Singer et al.
patent: 5989835 (1999-11-01), Dunlay et al.
patent: 5991028 (1999-11-01), Cabib et al.
patent: 5995143 (1999-11-01), Price et al.
patent: 6007996 (1999-12-01), McNamara et al.
patent: 6008010 (1999-12-01), Greenberger et al.
patent: 6078681 (2000-06-01), Silver
patent: 6083763 (2000-07-01), Balch
patent: 6103479 (2000-08-01), Taylor
patent: 6146830 (2000-11-01), Friend et al.
patent: 6169816 (2001-01-01), Ravkin
patent: 6222093 (2001-04-01), Marton et al.
patent: 6345155 (2002-02-01), Tojo et al.
patent: 6615141 (2003-09-01), Sabry et al.
patent: 6658143 (2003-12-01), Hansen et al.
patent: 0317139 (1998-04-01), None
patent: 93/21511 (1993-10-01), None
patent: WO 95/22749 (1995-08-01), None
patent: 96/09605 (1996-03-01), None
patent: WO97/11094 (1997-03-01), None
patent: 97/43732 (1997-11-01), None
patent: WO 98/45704 (1998-10-01), None
patent: WO 98/52018 (1998-11-01), None
patent: 99/05323 (1999-02-01), None
patent: WO 99/17116 (1999-04-01), None
patent: WO 99/39184 (1999-08-01), None
patent: WO 99/54494 (1999-10-01), None
patent: WO 00/29984 (2000-05-01), None
patent: WO00/65472 (2000-11-01), None
patent: WO00/70528 (2000-11-01), None
patent: WO0135072 (2001-05-01), None
patent: WO02/50512 (2002-06-01), None
Stearns et al., Interleukin 10 (IL-10) Inhibition of Primary Human Prostate Cell-Induced Angiogenesis: IL-10 Stimulation of Tissue Inhibitor of Metalloproteinase-1 and Inhibition of Matrix Metalloproteinase (MMP)-2/MMP-9 Secretion, Clinical Research, vol. 5, 189-196, Jan. 1999.
Russ, J. C. “The Image Processing Handbook,” Second Edition, Boca Raton, CRC Press, 1995, pp. 457-461 and 469-474.
Lu et al., Hierarchical Shape Recognition Using Polygon Approximation and Dynamic Alignment, IEEE Paper CH2561-9, vol. 2, pp. 976-979, 1988.
Cormack et al., FACS-optimized mutants of the green fluorescent protein (GFP),Gene. 173(1996) 33-38.
Craig et al., “IS hsp 70 the cellular thermometer?” TIBS 16,Apr. 1991.
Cubitt et al., “Understanding, improving and using green fluorescent proteins,” Elsevier Science Ltd., 0968-00004/95, Nov. 1995.
Dobson et al., “Dynamics of insulin-stimulated translocation of GLUT4 in single living cells visualized using green fluorescent protein,” Federation of European Biochemical Societies, 1996.
Georget et al., “Trafficking of the androgen receptor in living cells with fused green fluorescent protein—androgen receptor,” Molecular and Cellular Endocrinology 129 (1997) 17-26.
Lippincott-Schwartz, “Insights into secretory and endocytic membrane traffic using green fluorescent protein chimeras,”Current Opinion in Neurobiology, vol. 7, pp. 631-639 1997.
Misteli, Tom and Spector, David L., “Applications of the green fluorescent protein in cell biology and biotechnology”, 1997,Nature Biotechnology, vol. 15, pp. 961-964.
Palm, Gottfried J. et al., “The structural basis for spectral variations in green fluorescent protein”, 1997,Nature Structural Biology, vol. 4, No. 5, pp. 361-365.
Sakai, Kenji et al., “Purification and characterization of N-acyl-D-glutamate deacylase fromAlcaligenes xylosoxoydansA-6”, 1991,FEBS Letters, vol. 289, No. 1, pp. 44-46.
Shulga, Nataliya et al., “In Vivo Nuclear Transport Kinetics inSaccharamyces cerevisiae: A Role for Heat Shock Protein 70 during Targeting and Translocation”, 1996,The Journal of Cell Biology, vol. 135, No. 2, pp. 329-339.
Tarasova, Nadya I. et al., “Visualization of G Protein-coupled Receptor Trafficking with the Aid of the Green Fluorescent Protein”,The Journal of Biological Chemistry, vol. 272, No. 23, Issue of Jun. 6, pp. 14817-14824.
Welsh, Stephen and Kay, Steve A., “Reporter gene expression for monitoring gene transfer”, 1997,Current Opinion in Biotechnology, vol. 8, pp. 617-622.
Boland, Micheael et al., Automated Recognition of Patterns Characteristic of Subcellular Structures in Fluorescence Microscopy Images, Rapid Communications, 1998 Cytometry, 33:366-375.
Wang et al., “Immunolocalization of 6”, His-tagged pr in CHO cells with anti-His antibodies, Dec. 1999.
Kapur et al., “Design and Fabrication of Spatially Controlled Miniatutrized Organ Systems from Stem Cells,” U.S. Appl. No. 60/127,339, filed Apr. 1, 1999.
Adams et al., “Cell Patterning on Glass and Polymeric Substrates” U.S. Appl. No. 60/138,119, filed Jun. 7, 1999.
Cseke, I., “A fast segmentation scheme for white blood cell images” (1992) IEEE, pp. 530-533.
Hartwell et al., “Integrating genetic approaches into the discovery of anticancer drugs,” (1997) Science 278:1064-1068.
Hofland et al., “Role of tumor-derived fibroblasts in the growth of primary cultures of human breast-cancer cells: effects of epidermal growth factor and the somatostatin analogue octreotide” (1995), Int. J. Cancer: 60:93-99.
Ng et al., “Evaluating multi-dimensional indexing structures for images transformed by principal component analysis,” Proceedings of SPIE, Bellingham, Spie, US (1996), vol. 2670, pp. 50-61.
Takayama et al., “Patterning cells and their environments using multiple laminar fluid flows in capillary networks,” (1999) Proc. Natl., Acad. Sci. USA, 96:5545-5548.
Pauwels et al., “Determination of the Mechanism of Action of Anticancer Drugs by Means of the Computer-Assisted Microscope Image Analysis of Feulgen-Stained Nuclei”, J. Pharmacological and Toxicological Methods. 37: 105-115 (1997).
Rubas, et al., “An Integrated Method to Determine Epithelial Transport and Bioactivity of Oral Drug Candidates in Vitro,” Pharmaceutical Research, vol. 13, No. 1, (1996) pp 23-27.
Sunblad et al., “The use of image analysis and automation for
Adams Cynthia L.
Oestreicher Donald R.
Vaisberg Eugeni A.
Beyer Weaver & Thomas LLP
Clow Lori A.
Cytokinetics Inc.
Moran Marjorie A.
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