Characterized BRCA1 and BRCA2 proteins and screening and therape

Details Characterized BRCA1 and BRCA2 proteins and screening and therape Characterized BRCA1 and BRCA2 proteins and screening and therape

1998-06-18

2000-11-21

Priebe, Scott D.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

514 44, 536 231, 4353201, 435325, 435455, 435458, A61K 4800

Patent

active

06149903&

ABSTRACT:
Genetic analysis of familial breast and ovarian cancer indicates that BRCA1 is a tumor suppressor gene. The BRCA1 gene encodes a 190 kDa protein with sequence homology and biochemical analogy to the granin family of proteins. Granins are secreted from endocrine cells via the regulated secretory pathway and are proteolytically cleaved to yield biologically active peptides. BRCA1 protein localizes to secretory vesicles, and was demonstrated to be secreted. Gene transfer of BRCA1 inhibits growth and tumorigenesis of breast and ovarian cancer cells, but not colon or lung cancer cells or fibroblasts, suggesting that BRCA1 encodes a tissue-specific growth inhibitor. Thus, BRCA1 is a secreted growth inhibitor and functions by a mechanism not previously described for tumor suppressor genes. The BRCA2 breast and ovarian cancer gene encodes a protein that also includes a granin region, indicating that the BRCA2 protein is also a secreted tumor suppressor. Therapeutic methods using the BRCA1 and BRCA proteins and genes are also described. A method of screening for the receptors of the BRCA1 protein and BRCA2 proteins is also described.

REFERENCES:
patent: 4675285 (1987-06-01), Clark et al.
patent: 5399346 (1995-03-01), Anderson et al.
patent: 5434064 (1995-07-01), Schlessinger et al.
patent: 5654155 (1997-08-01), Murphy et al.
patent: 5891857 (1999-04-01), Holt et al.
Meng et al., Gene Therapy of Cancer, Chapter 1, pp. 3-20, 1999.
Tait et al., Breast Disease, 10, 1,2, 89-98, 1998.
Anderson, Nature, vol. 392, 25-30, Apr. 1998.
Tait et al., Clinical Cancer Res., vol. 5, 1707-1714, 1999.
Wooster et al., "Identification of the Breast Cancer Susceptibility Gene BRCA2", Nature, vol. 378, (Dec. 21/28 1995), pp. 789-792.
Miki et al., "A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1", Science, vol. 1, (Oct. 7, 1994), pp. 66-71.
Holt et al., "Growth Retardation and Tumour Inhibition by BRCA1", Nature Genetics, vol. 12, (Mar. 1996), pp. 298-302.
Ormiston, "Hereditary Breast Cancer", European Journal of Cancer Care, vol. 5, (1996), pp. 13-20.
Jones et al., "Molecular Genetics of Sporadic and Familial Breast Cancer", Cancer Surveys, vol. 25, (1995), pp. 315-334.
"Molecular Biology/Biochemistry", Proceedings of the American Association for Breast Cancer Research, vol. 37, (Mar. 1996), p. 516.
Chen et al., "Aberrant Subcellular Localization of BRCA1 in Breast Cancer", Science, vol. 270, (Nov. 3, 1995), pp. 789-791.
Cornelius et al., "High Allele Loss Rates at 17q12-q21 in Breast and Ovarian Tumors from BRCA1-Linked Families", Genes, Chromosomes & Cancer, vol. 13, (1995), pp. 201-210.
Gayther et al., "Germline Mutations of the BRCA1 Gene in Breast and Ovarian Cancer Families Provide Evidence for a Genotype-Phenotype Correlation", Nature Genetics, vol. 11, (Dec. 1995), pp. 428-433.
Gudas et al., "Hormone-Dependent Regulation of BRCA1 in Human Breast Cancer Cells", Cancer Research, vol. 55, (Oct. 15, 1995), pp. 4561-4565.
Hosking et al., "A Somatic BRCA1 Mutation in an Ovarian Tumour", Nature Genetics, vol. 9, (Apr. 1995), pp. 343-344.
Huttner et al., "The Granin (Chromogranin/Secretogranin) Family", TIBS, vol. 16, (Jan. 1991), pp. 27-30.
Marquis et al., "The Developmental Pattern of BRCA1 Expression Implies a Role in Differentiation of the Breast and Other Tissues", Nature Genetics, vol. 11, (Sep. 1995), pp. 17-26.
Merajver et al., "Somatic Mutations in the BRCA1 Gene in Sporadic Ovarian Tumours", Nature Genetics, vol. 9, (Apr. 1995), pp. 439-443.
Thompson et al., "Decreased Expression of BRCA1 Accelerates Growth and is Often Present During Sporadic Breast Cancer Progression", Nature Genetics, vol. 9, (Apr. 1995), pp. 444-450.
Lemoine, "Molecular Biology of Breast Cancer", Annals of Oncology, 5 (Supp. 4) pp. S31-S37.
Weber et al., "Familial Breast Cancer", Cancer Supplement, vol. 74, No. 3, (Aug. 1, 1994), pp. 1013-1020.
Takahashi et al., "Mutation Analysis of the BRCA1 Gene in Ovarian Cancers", Cancer Research, vol. 55, (Jul. 15, 1995), pp. 2998-3002.
Narod, "Genetics of Breast and Ovariana Cancer", British Medical Bulletin, vol. 50, No. 3, (1994), pp. 656-676.
Hall et al., "Linkage of Early-Onset Familial Breast Cancer to Chromosome 17q21", Science, vol. 250, (Dec. 21, 1990), pp. 1684-1689.
Helzlsouer, "Epidemiology, Prevention and Early Detection of Breast Cancer", Current Opinion in Oncology, vol. 7, (1995), pp. 489-494.
Szabo et al., "Inherited Breast and Ovarian Cancer", Human Molecular Genetics, vol. 4, pp. 1811-1817.
Easton et al., "Inherited Susceptibility to Breast Cancer", Cancer Surveys, vol. 18, pp. 95-113.
Steeg, "Granin Expectations in Breast Cancer?", Nature Genetics, vol. 12, (Mar. 1996), pp. 223-225.
Burtness, "Oncology and Hematology", JAMA, vol. 273, No. 21, (Jun. 7, 1995), pp. 1702-1703.
Hopkin, "MTS1, Telomerase May be New Targets for Cancer Therapy", The Journal of NIH Research, vol. 6, (Jun. 1994), pp. 38-42.
Norris et al., "Identification of a New Subclass of Alu DNA Repeats Which Function as Estrogen Receptor-Dependent Transcriptional Enhancers", Journal of Biological Chemistry, vol. 270, No. 39, (Sep. 29, 1995), pp. 22777-22782.
Davis et al., "S.sub.1 Nuclease Protection Assay", Basic Methods in Molecular Biology, (1986), pp. 276-284.
Futreal et al., "BRCA1 Mutations in Primary Breast and Ovarian Carcinomas", Science, vol. 266, (Oct. 7, 1994), pp. 120-122.
Holt et al., "Histopathology: Old Principles and New Methods", Cancer Surveys, vol. 18, (1993), pp. 1-24.
Liang et al., "Differential Display and Cloning of a Messenger RNAs from Human Breast Cancer versus Mammary Epithelial Cells", Cancer Research, vol. 52, (Dec. 15, 1992), pp. 6966-6968.
Campbell et al., "A Novel Gene Encoding a B-Box Protein Within the BRCA1 Region at 17q21.1", Human Molecular Genetics, vol. 3, No. 4, (1994), pp. 589-594.
Narod et al., "An Evaluation of Genetic Heterogeneity in 145 Breast-Ovarian Cancer Families", Am. J. Hum. Genet., vol. 56, (1995), pp. 254-264.
Marcus et al., "Pathology and Heredity of Breast Cancer in Younger Women", Journal of the National Cancer Institute Monographs, No. 16, (1994), pp. 23-33.
Porter et al., "Breast Cancer Incidence, Penetrance and Survival in Probable Carriers of BRCA1 Gene Mutations in Families Linked to BRCA1 on Chromosome 17q12-21", British Journal of Surgery, vol. 81, (1994), pp. 1512-1515.
Merlo et al., "Evidence for a Second Tumor Suppressor Gene on 17p Linked to High S-Phase Index in Primary Human Breast Carcinomas", Cancer Genet. Cytogenet., vol. 76, (1994), pp. 106-111.
Neuhausen et al., "Loss of Heterozygosity in Familial Tumors from Three BRCA1-Linked Kindreds", Cancer Research, vol. 54, (Dec. 1, 1994), pp. 6069-6072.
Brown et al., "Regulation of BRCA1", Nature, vol. 372, (Dec. 22/29 1994), p. 733.
Simard et al., "Common Origins of BRCA1 Mutations in Canadian Breast and Ovarian Cancer Families", Nature Genetics, vol. 8, (Dec. 1994).
Castilla et al., "Mutations in the BRCA1 Gene in Families with Early-Onset Breast and Ovarian Cancer", Nature Genetics, vol. 8, (Dec. 1994), pp. 387-391.
Friedman et al., "Confirmation of BRCA1 by Analysis of Germline Mutations Linked to Breast and Ovarian Cancer in Ten Families", Nature Genetics, pp. 1-6.
Guzburg et al., "Virus Vector Design in Gene Therapy", Molecular Medicine Today, (1995), pp. 410-417.
Reeck et al., "`Homology` in Proteins and Nucleic Acids: A Terminology Muddle and a Way Out of It", Cell., vol. 59(Aug. 28, 1987), p. 667.
Ledley, "Nonviral Gene Therapy: The Promise of Genes as Pharmaceutical Products", Human Gene Therapy, vol. 6, (Sep. 1995), pp. 1129-1144.
Marshall, "Less Hype, More Biology Needed for Gene Therapy", Science, (Dec. 1995), p. 1751.
Coghlan, "Gene Dream Fades Away", New Scientist, (Nov. 1995).
Jain, "Barriers to Drug Delivery in Solid Tumors", Scientific American, (Jul. 1994), pp. 58-65.
Mastrangelo et al., "Gene Therapy for Human Cancer: An Essay for Clinicians", Seminars in Oncology, vol. 23, No. 1, (Feb. 1996), pp. 4-21.
Wallace et al., "Oligonucleotide Probes for the Screening of Recombinant DNA Libraries", Methods in Enzymology, vol. 152, (1987), pp. 432-4

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