Characterization of platelet aggregation disorders

Details Characterization of platelet aggregation disorders Characterization of platelet aggregation disorders

1990-11-15

1993-03-23

Saunders, David

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 724, 436503, 436548, G01N 33567, G01N 33577

Patent

active

051963094

ABSTRACT:
Methods are described for characterizing platelet aggregation defects. The defects are characterized as activation, ligand binding, or post-occupancy defects. In one embodiment of the invention a Cam variant of Glanzmann's thrombasthenia is characterized as having a ligand binding defect. In another embodiment, a patient with myelofibrosis is identified as having an activation defect. Rapid analysis are afforded using fluorescence-activated flow cytometry. Also, diagnostic kits are described which comprise antibodies suitable for characterizing the above defects.

REFERENCES:
patent: 4783330 (1988-11-01), Furie et al.
patent: 4820505 (1989-04-01), Ginsberg et al.
Abrams, et al., Blood 70: abst. no. 1196 (1987).
Shattil et al., J. Biol. Chem. 260: 11107 (1985).
Lam, et al., J. Biol. Chem. 262: 947-950 (1987).
Frelinger, et al., J. Biol. Chem. 265: 6346 (1990).
Shadle et al., J. Cell Biol. 99: 2056-60 (1984).
Zamarron et al., Blood 74: 208a (Suppl. 1) (1989).
D'Souza et al., J. Biol. Chem. 265: 3440 (1990).
A. L. Frelinger III, Jour. Biol. Chem., 263, 12397-12402, 1988.

Affiliated with

Also associated with

Rating

Characterization of platelet aggregation disorders does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Characterization of platelet aggregation disorders, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Characterization of platelet aggregation disorders will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1350899