Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-06-23
1997-08-12
Saunders, David
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 724, 435975, 436548, G01N 33567, G01N 33577
Patent
active
056564422
ABSTRACT:
Methods are described for characterizing platelet aggregation defects. The defects are characterized as activation, ligand binding, or post-occupancy defects. In one embodiment of the invention a Cam variant of Glanzmann's thrombasthenia is characterized as having a ligand binding defect. In another embodiment, a patient with myelofibrosis is identified as having an activation defect. Rapid analysis are afforded using fluorescence-activated flow cytometry. Also, diagnostic kits are described which comprise antibodies suitable for characterizing the above defects.
REFERENCES:
patent: 4783330 (1988-11-01), Furie et al.
patent: 4820505 (1989-04-01), Ginsberg et al.
patent: 5114842 (1992-05-01), Plow et al.
Shattil, et al., J. Biol. Chem. 260: 11107 (1985).
Lam, et al., J. Biol. Chem. 262: 947-950 (1987).
Frelinger, et al., J. Biol. Chem. 265: 6346 (1990).
Shadle, et al., J. Cell Biol. 99: 2056-60 (1984).
Zamarron, et al., Blood 74: 208a (Suppl. 1) (1989).
D'Souza, et al., J. Biol. Chem. 265: 3440 (1990).
Frelinger, et al., J. Biol. Chem. 263: 12397-12402 (1988).
Abrams, et al., Blood 70: abst. No. 1196 (1987).
Fitting Thomas
Saunders David
The Scripps Research Institute
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