Characterization of phenotypes by gene expression patterns...

Details Characterization of phenotypes by gene expression patterns... Characterization of phenotypes by gene expression patterns...

2009-10-06

2010-12-28

Clow, Lori A (Department: 1631)

Data processing: measuring, calibrating, or testing

Measurement system in a specific environment

Biological or biochemical

C702S032000, C702S179000

Reexamination Certificate

active

07860660

ABSTRACT:
Generally, the present invention applies a transformation to convert a probability distribution of gene expression signals in control samples to a uniform distribution. The uniform distribution allows better comparisons between expression levels for genes. The transformation is derived from gene expression signals of control data, and is applied to gene expression signals of phenotype data. The phenotype data can be represented in a matrix format. A number of gene expression patterns may be determined (in the form of submatrices) that will characterize the phenotype. The uniform distribution helps in this regard, as it allows better comparisons of patterns. The gene expression patterns can then be used to classify samples as belonging to the phenotype set. Preferably, a discriminant function is used to compare a sample with the gene expression patterns that characterize the phenotype. The discriminant function can determine a score that can be used to determine whether the sample belongs to the phenotype.

REFERENCES:
Alizadeh (2000) Nature vol. 403, Feb. 3, pp. 503-511.
Alon (1999) PNAS vol. 96, June pp. 6745-6750.
Ben-Dor (1999) Journal of Computational Biology, vol. 6, pp. 281-297.
Brown (2000) PNAS vol. 97, January pp. 262-267.
DeRisi (1996) Nature Genetics vol. 14, December pp. 457-460.
Golub (1999) Science vol. 286, October pp. 531-537.
Kerr (2000) Journal of Computational Biology vol. 7, pp. 819-837.
Ross (2000) Nature Genetics vol. 24, March pp. 227-235.
Tamayo (1999) PNAS vol. 96, March pp. 2907-2912.

Affiliated with

Also associated with

Rating

Characterization of phenotypes by gene expression patterns... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Characterization of phenotypes by gene expression patterns..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Characterization of phenotypes by gene expression patterns... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4194630