Characterization of novel gene cbl-SL

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C424S278100, C435S069100, C435S253300, C435S320100

Reexamination Certificate

active

06867292

ABSTRACT:
The invention pertains to nucleic acids encoding a cbl-SL protein, including fragments and biologically functional variants thereof. The invention also pertains to therapeutics and diagnostics involving the foregoing proteins and genes and agents that bind the foregoing proteins and genes.

REFERENCES:
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Voet. Biochemistry p. 126-128 & 228-234, 1990.*
Erdreich-Epstein A et al., “Cbl Functions Downstream of Src Kinases in Fc Gamma RI Signaling in Primary Human Macrophages,”J. Leukoc. Biol.1999, 65(4):523-34—Abstract Only.
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Levkowitz G et al., “c-Cbl/Sli-1 Regulates Endocytic Sorting and Ubiquitination of the Epidermal Growth Factor Receptor,”Genes Dev., 1998, 12(23):3663-74—Abstract Only.
McCarty JH et al., “The TrkB Receptor Tyrosine Kinase Regulates Cellular Proliferation Via Signal Transduction Pathways Involving SHC, PLCgamma, and CBL,”J. Recept. Signal Transduct. Res.1999, 19(6):953-74—Abstract Only.
Yokouchi, Masahiro et al., “Ligand-Induced Ubiquitination of the Epidermal Growth Factor Receptor Involves The Interaction of the c-Cbl RING Finger and UbcH7,”The Journal of Biological Chemistry, vol. 274, No. 44, 1999, pp. 31707-31712.
Joazeiro CA et al., “The Tyrosine Kinase Negative Regulator c-Cbl as a RING-Type, E2-Dependent Ubiquitin-Protein Ligase,”Science1999, 286(5438):309-12—Abstract Only.
van Leeuwen JE et al., “The Oncogenic 70Z cbl Mutation Blocks the Phosphotyrosine Binding Domain-Dependent Negative Regulation of ZAP-70 by c-Cbl in Jurkat T Cells,”Mol. Cell. Biol.1999, 19(10):6652-64—Abstract Only.
Waterman H et al., “The RING Finger of c-Cbl Mediates Desensitization of the Epidermal Growth Factor Receptor,”The Journal of Biological Chemistry, 1999, vol. 274, No. 32, pp. 22151-22154.
Lupher ML, et al., “The Cbl Protooncoprotein: A Negative Regulator of Immune Receptor Signal Transduction,”Immunology Today, 1999, vol. 20, No. 8, pp. 375-382.
Lee PS et al., “The Cbl Protooncoprotein Stimulates CSF-1 Receptor Multiubiquitination and Endocytosis, And Attenuates Macrophage Proliferation,”EMBO J.1999 18(13):3616-28—Abstract Only.
Feshchenko EA et al., “Tyrosine Phosphorylation of C-Cbl Facilitates Adhesion and Spreading While Suppressing Anchorage-Independent Growth of V-Abl-Transformed NIH3T3 Fibroblasts,”Oncogene, 1999, 18(25):3703-15—Abstract Only.
Keane MM et al., “cbl-3:A New Mammalian cbl Family Protein,”Oncogene1999, 18(22):3365-75 Abstract Only.
Broome MA et al., “The Proto-Oncogene c-Cbl is a Negative Regulator of DNA Synthesis Initiated by Both Receptor and Cytoplasmic Tyrosine Kinases,”Oncogene1999, 18(18):2908-12—Abstract Only.
Thien CB et al., “Perturbed Regulation of ZAP-70 and Sustained Tyrosine Phosphorylation of LAT and SLP-76 in c-Cbl-Deficient Thymocytes,”J. Immunol.1999, 162(12):7133-9—Abstract Only.
Miyake S et al., “Cbl-Mediated Negative Regulation of Platelet-Derived Growth Factor Receptor-Dependent Cell Proliferation,”The Journal of Biological Chemistry, 1999, vol. 274, No. 23, pp. 16619-16628.

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