Characterization of individual polymer molecules based on monome

Chemistry: analytical and immunological testing – Process or composition for determination of physical state...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

436151, 435 4, G01N 33483

Patent

active

057957827

ABSTRACT:
A method is disclosed for characterizing a linear polymer molecule by measuring physical changes across an interface between two pools of media as the linear polymer traverses the interface and monomers of the polymer interact with the interface, where the physical changes are suitable to identify characteristics of the polymer.

REFERENCES:
Auld et al., "A Neutral Amino Acid Change in Segment IIS4 Dramatically Alters the Gating Properties of the Voltage-Dependent Sodium Channel", 1990, Proc. Natl. Acad. Sci. USA, 87:323-27.
Bensimon, A., et al., "Alignment and Sensitive Detection of DNA by a Moving Interface", 1994, Science, 265:2096-98.
Benz et al., "Pore Formation by LamB of Escherichia Coli in Lipid Bilayer Membranes", 1986, J. Bacteriology, 165(3):978-86.
Benz et al., "Mechanism of Sugar Transplant through the Sugar-Specific LamB Channel of Escherichia Coli Outer Membrane", 1987, J. Membrane Biol., 100:21-29.
Bezrukov et al., "Counting Polymers Moving Through a Single Ion Channel", 1994, Nature, 370:279-81.
Boulain et al., "Mutagenesis by Random Linker Insertion into the LamB Gene of Escherichia Coli K12", 1986, Mol. Gen. Genet., 205:339-48.
Boulanger et al., "Characterization of Ion Channels Involved in the Penetration of Phage T4 DNA into Escherichia Coli Cells", 1988, J. Biolog. Chem., 263(20):9767-75.
Boulanger et al., "Ion Channels Are Likely to Be Involved in the Two Steps of Phage T5 DNA Penetration into Escherichia Coli Cells", 1992, J. Biolog. Chem., 267(5):3168-72.
Boyd et al., "Determinants of Membrane Protein Topology", 1987, Proc. Natl. Acad. Sci. USA, 84:8525-29.
Charbit et al., "Permissive Sites and Topology of an Outer Membrane Protein with a Reporter Epitope", 1991, J. Bacteriology, 173(1):262-75.
Dargent et al., "Selectivity for Maltose and Maltodextrins of Maltoporin, a Pore-Forming Protein of E. Coli Outer Membrane", 1987, FEB Letters, 220(1):136-42.
Dargent et al., "Effect of Point Mutations on the in-Vitro Pore Properties of Maltoporin, a Protein of Escherichia Coli Outer Membrane", 1988, J. Mol. Biol., 201:497-506.
DeBlois et al., "Electrokinetic Measurements with Submicron Particles and Pores by the Resistive Pulse Technique", 1977, J. Colloid and Interface Science, 61(2):323-35.
Ehrmann et al., "Genetic Analysis of Membrane Protein Topology by a Sandwich Gene Fusion Approach", 1990, Proc. Natl. Acad. Sci. USA, 87:7574-78.
Ferenci et al., "Channel Architecture in Maltoporin: Dominance Studies with LamB Mutations Influencing Maltodextrin Binding Provide Evidence for Independent Selectivity Filters in Each Subunit", 1989, J. Bacteriology, 171(2):855-61.
Ghadiri et al., "Artificial Transmembrane Ion Channels From Self-Assembling Peptide Nanotubes", 1994, Nature, 369:301-304.
Hall et al., "Alamethicin: A Rich Model for Channel Behavior", 1984, J. Biophys., 45:233-47.
Hamill et al., "Improved Patch-Clamp Techniques for High-Resolution Current Recording from Cells and Cell-Free Membrane Patches", 1981, Pflugers Archiv. Eur. J. Physiology, 391(2):85-100.
Harrington et al., "The F Pilus of Escherichia Coli Appears to Support Stable DNA Transfer in the Absence of Wall-to-Wall Contact Between Cells", 1990, J. Bacteriology, 172(12):7263-64.
Heinemann et al., "Open Channel Noise IV: Estimation of Rapid Kinetics of Formamide Block in Gramicidin A Channels", 1988, J. Biophys., 54:757-64.
Heinemann et al., "Open Channel Noise V: Fluctuating Barriers to Ion Entry in Gramicidin A Channels", 1990, J. Biophys., 57:499-514.
Henry et al., "Blockade of a Mitochondrial Cationic Channel by an Addressing Peptide: An Electrophysiological Study", 1989, J. Membranee Biol., 112:139-47.
Hoshi et al., "Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation", 1990, Science, 250:533-38.
Hoshi et al., "Two Types of Inactivation in Shaker K.sup.+ Channels: Effects of Alterations in the Carboxy-Terminal Region", 1991, Neuron, 7:547-56.
Kubitschek, "Electronic Counting and Sizing of Bacteria", Nature, 1958, 182:234-35.
Lakey et al., "The Voltage-Dependent Activity of Escherichia Coli Porins in Different Planar Bilayer Reconstitutions", 1989, Eur. J. Biochem., 186:303-308.
Lopez et al., "Hydrophobic Substitution Mutations in the S4 Sequence Alter Voltage-Dependent Gating in Shaker K.sup.+ Channels", 1991, Neuron, 7:327-36.
Moellerfeld et al., "Improved Stability of Black Lipid Membranes by Coating with Polysaccharide Derivatives Bearing Hydrophibic Anchor Groups", 1986, Biochimica et Biophysica Acta, 857:265-70.
Nath et al., "Transcription by T7 RNA Polymerase Using
Neher et al., "Single-Channel Currents Recorded from Membrane of Denervated Frog Muscle Fibres", 1976, Nature, 260:799-801.
Novick et al., "Fluorescence Measurement of the Kinetics of DNA Injection by Bacteriophage l into Liposomes", 1988, Biochemistry, 27:7919-24.
Ollis et al., "Domain of E. Coli DNA Polymerase I Showing Sequence Homology to T7 DNA Polymerase", 1985, Nature, 313:818-19.
Ollis et al., "Structure of Large Fragment of Escherichia Coli DNA Polymerase I Complexed with dTMP", 1985, Nature, 313:762-66.
Ovchinnikov et al., 3. The Cyclic Peptides: Structure, Conformation, and Function: P. Gramicidin S. (851), Its Analogs and Tyrocidines A-C (904-906), 1982, The Proteins, Third Edition, 5:547-55.
Ovchinnikov et al., 3. The Cyclic Peptides: Structure, Conformation, and Function: T. Valinomycin (913), 1982, The Proteins, Third Edition, 5:563-73.
Patton et al., "Amino Acid Residues Required for Fast Na.sup.+ -channel Inactivation: Charge Neutralizations and Deletions in the III-IV Linker", 1992, Proc. Natl. Acad. Sci. USA, 89:10905-909.
Shiver et al., "On the Explanation of the Acidic pH Requirement for In Vitro Activity of Colicin E1", 1987, J. Biological Chem., 262(29):14273-281.
Sigworth et al., "Open Channel Noise: III. High Resolution Recordings Show Rapid Current Fluctations in Gramicidin A and Four Chemical Analogues", 1987, J. Biophys., 52:1055-64.
Simon et al., "A Protein Conducting Channel in the Endoplasmic Reticulum", Cell, 65:371-80, (1991).
Taylor et al., "`Reversed` Alamethicin Conductance in Lipid Bilayers", 1991, J. Biophys., 59:873-79.
Weiss et al., "Molecular Architecture and Electrostatic Properties of a Bacterial Porin", 1991, Science, 254:1627-30.
West et al., "A Cluster of Hydrophobic Amino Acid Residues Required for Fast Na.sup.+ -channel Inactivation", 1992, Proc. Natl. Acad. Sci. USA, 89:10910-14.
Wonderlin et al., "Optimizing Planar Lipid Bilayer Single-Channel Recordings for High Resolution with Rapid Voltage Steps", 1990, J. Biophys., 58:289-97.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Characterization of individual polymer molecules based on monome does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Characterization of individual polymer molecules based on monome, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Characterization of individual polymer molecules based on monome will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1114070

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.