Characterization of individual polymer molecules based on monome

Details Characterization of individual polymer molecules based on monome Characterization of individual polymer molecules based on monome

1998-06-16

2000-01-18

Patterson, Jr., Charles L.

Chemistry: analytical and immunological testing

Process or composition for determination of physical state...

436151, 435 4, G01N 33483

Patent

active

060157143

ABSTRACT:
A method for sequencing a nucleic acid polymer by (1) providing two separate, adjacent pools of a medium and an interface between the two pools, the interface having a channel so dimensioned as to allow sequential monomer-by-monomer passage from one pool to the other pool of only one nucleic acid polymer at a time; (2) placing the nucleic acid polymer to be sequenced in one of the two pools; and (3) taking measurements as each of the nucleotide monomers of the nucleic acid polymer passes through the channel so as to sequence the nucleic acid polymer.

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