Chemistry: molecular biology and microbiology – Maintaining blood or sperm in a physiologically active state...
Patent
1996-04-26
1998-12-01
Eisenschenk, Frank C.
Chemistry: molecular biology and microbiology
Maintaining blood or sperm in a physiologically active state...
435326, 435346, 4353721, 435 721, 435343, 5303887, 5303896, 5303913, C12N 520, C12P 2108, C07K 1628
Patent
active
058436332
ABSTRACT:
An hematopoietic progenitor cell antigen, and antibodies that specifically bind to the antigen are provided. Expression of the antigen is highly tissue specific. It is only detected on a subset of hematopoietic progenitor cells derived from human bone marrow, fetal bone marrow and liver, cord blood and adult peripheral blood. The subset of cells recognized by AC133 is CD34.sup.bright, and contains substantially all of the CFU-GM activity present in the CD34.sup.+ population. This highly specific distribution of AC133 makes it exceptionally useful as a reagent for isolating and characterizing human hematopoietic progenitor and stem cells. Cells selected for expression of AC133 antigen may be further purified by selection for other hematopoietic stem cell and progenitor cell markers.
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Buck David W.
Miraglia Sheri
Yin Amy
AmCell Corporation
Eisenschenk Frank C.
Godward LLP Cooley
Rabin Evelyn
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