Chemistry: analytical and immunological testing – Biospecific ligand binding assay
Reexamination Certificate
2011-05-31
2011-05-31
Shafer, Shulamith H (Department: 1647)
Chemistry: analytical and immunological testing
Biospecific ligand binding assay
C435S007100, C435S002000
Reexamination Certificate
active
07951613
ABSTRACT:
Methods of use of Chaperonin 10 (Cpn10) are provided for regulating Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion. Cpn10 negatively regulates Toll-like receptor agonist-induced pro-inflammatory cytokine and chemokine secretion, examples being IL-6 and RANTES, respectively. Cpn10 positively regulates Toll-like receptor agonist-induced anti-inflammatory cytokine and chemokine secretion, an example being IL-10. These immunoregulatory activities of Cpn10 may be useful in the treatment of diseases, disorders and conditions resulting from excessive pro-inflammatory cytokine and chemokine secretion. This invention also relates to producing, designing and/or screening Cpn10 agonists and antagonists according to their ability to regulate Toll-like receptor signaling and/or Toll-like receptor inducible immunomodulator secretion.
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Dobbin Caroline Amanda
Howard Christopher Bruce
Johnson Barbara Jane
Naylor Dean Jason
Suhrbier Andreas
CBIO Limited
Knobbe Martens Olson & Bear LLP
Shafer Shulamith H
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