Chaperonin 10 immunosuppression

Details Chaperonin 10 immunosuppression Chaperonin 10 immunosuppression

2003-11-06

2009-11-17

Schwadron, Ron (Department: 1644)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S350000, C530S380000

Reexamination Certificate

active

07618935

ABSTRACT:
The invention is directed to the use of cpnl0 in transplantation and particularly to treatment and/or prevention of graft versus host disease. The invention provides a method of administration of cpn10 to a donor and/or recipient animal or cells, tissues or organs derived from the donor, although in a particularly advantageous form treatment of both the donor and recipient animal. The method may further include the administration to the donor and/or recipient animal at least one other immunosuppressive agent to prevent or alleviate graft versus host disease.

REFERENCES:
patent: 6117421 (2000-09-01), Morton et al.
patent: 6417334 (2002-07-01), Morton et al.
patent: WO 01/17554 (2001-03-01), None
patent: WO 02/40038 (2002-05-01), None
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Noonan et al., “Early pregnancy factor is immunosuppressive.” Nature, 278, 649-51, (1979).
Ogita et al., “Stress Responses in Graft and Native Intestine After Rat Heterotopic Small Bowel Transplantaion.” Transplantation, 69, 2273-2277, (2000).
Rolfe et al., “Identification of two suppressor factors induced by early pregnancy factor.” Clin. Exp. Immunol., 73, 2 19-225, (1988).
Ryan et al., “Isolation of a cDNA clone specifying rat chaperonin 10, a stress-inducible mitochondrial matrix protein synthesised without a cleavable presequence.” FEBS Lett., 337, 152-156 (1994).
Speiser et al., “TNF Receptor p55 Controls Early Acute Graft-Versus-Host Disease.” J. Immunol., 158, 5185-5190, (1997).
Morton et al., Production of a recombinant form of early pregnancy factor that can prolong allogeneic skin graft survival time in rats. Immunology and Cell Biology, 78:6, p. 603-607, Dec. 2000. XP002463561.
Cooke et al., “LPS antagonism reduces graft-versus host disease and preserves graft-versus-leukemia activity after experimental bone marrow transplantation.” J. Clin. Invest., 107, 1581-1589(2001).
Morton et al., “Immunosuppression detected in pregnant mice by rosette inhibition test.” Nature, 249; 459-460, (1974).

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