Chamber for the optical manipulation of microscopic particles

Details Chamber for the optical manipulation of microscopic particles Chamber for the optical manipulation of microscopic particles

1989-11-30

1992-03-31

Warden, Robert J.

Chemical apparatus and process disinfecting, deodorizing, preser

Control element responsive to a sensed operating condition

Control element responds proportionally to a variable signal...

422 58, 422 681, 422 8205, 356244, 359350, G01N 2100, G01N 3101, G02B 0000

Patent

active

051006278

ABSTRACT:
A particle control chamber enables experiments to be carried out on biological cells and the like using a laser system to trap and manipulate the particles. A manipulation chamber provides a plurality of inlet and outlet ports for the particles and for fluids used to control or to contact the particles. A central manipulation area is optically accessible by the laser and includes first enlarged volumes for containing a selected number of particles for experimentation. A number of first enlarged volumes are connected by flow channels through second enlarged volumes. The second enlarged volumes act as bubble valves for controlling the interconnections between the first enlarged volumes. Electrode surfaces may be applied above the first enlarged volumes to enable experimentation using the application of electric fields within the first enlarged volumes. A variety of chemical and environmental conditions may be established within individual first enlarged volumes to enable experimental conditions for small scale cellular interactions.

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patent: 4983038 (1991-01-01), Ohki et al.
Ashkin et al., "Optical Trapping and Manipulation of Viruses and Bacteria", Science, vol. 235, 3/20/87, pp. 1517-1520.
Ashkin et al., "Optical Trapping and Manipulation of Single Cells Using Infrared Laser Beams"; Nature, vol. 330, 24/31, 12/1987, pp. 769-771.
Buiran et al., "New Technilogies in Cytometry", Proceedings of SPIE, vol. 1063, 1989, pp. 189-197.

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