Chalcophospholanes useful in the synthesis of oligonucleoside ph

Details Chalcophospholanes useful in the synthesis of oligonucleoside ph Chalcophospholanes useful in the synthesis of oligonucleoside ph

1992-05-12

1994-10-25

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 268, 536 2533, C07H 1910, C07H 1920

Patent

active

053590520

ABSTRACT:
Methods and compounds are provided for solid phase synthesis of oligonucleotides and related polymers by condensing protected monomer-O-[1,3,2-dichalcogen-substituted-phospholane] synthons in the presence of a catalytic base. Compounds of the invention include 2-N-substituted-1,3,2-dichalcogen-substituted-phospholane precursors of the above synthons, the protected monomer-O-[1,3,2-dichalcogen-substituted-phospholane] synthons, and P-chiral oligonucleotides and related P-chiral polymers.

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