Chalcone derivatives

Details Chalcone derivatives Chalcone derivatives

1978-03-03

1980-02-26

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

562463, 562464, 2603433R, 260507R, 424279, 260511, C07C 6522, A61K 3119, C07C 6520

Patent

active

041906713

ABSTRACT:
The present invention provides new chalcone derivatives of the general formula: ##STR1## wherein R.sub.1 is a hydroxyl, carboxylic acid or sulphonic acid group or a carboxyalkoxy or sulphoalkoxy radical, R.sub.2 and R.sub.3, which may be the same or different, are hydrogen or halogen atoms, hydroxyl groups or alkoxy radicals and R.sub.4 is an alkyl, hydroxyalkyl, alkoxy, carboxyalkoxy, sulphoalkoxy or carboxyalkylcarbonyloxyalkyl radical or a carboxylic acid or sulphonic acid group, with the proviso that compounds of general formula (Ia) always contain at least one carboxylic acid or sulphonic acid group; and the non-toxic inorganic and organic salts of those compounds containing at least one carboxylic acid or sulphonic acid group, the compounds of the invention are useful for treating inflammatory and allergic conditions and for treating ulcerous conditions of the gastro-intestinal tract in humans.

REFERENCES:
patent: 3255241 (1966-06-01), Schultz et al.
patent: 3928421 (1975-12-01), Kyogoku et al.
patent: 3956375 (1976-05-01), Farkas et al.
patent: 3994955 (1976-11-01), Sprenger
patent: 4085135 (1978-04-01), Kyogoku et al.

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