Chalcone derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

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560 51, 514533, 549230, 260507R, C07C 6976

Patent

active

046563059

ABSTRACT:
The present invention provides chalcone derivatives of the general formulae: ##STR1## wherein R.sub.1 is a hydroxyl, carboxylic or sulphonic acid group or a carboxyalkoxy or sulphoalkoxy radical, R.sub.2 is an unsaturated, straight-chained or branched aliphatic hydrocarbonyloxy radical, R.sub.3 is a hydrogen atom, a hydroxyl group or an alkoxy radical, R.sub.4 is an alkyl, hydroxyalkyl, alkoxy, carboxyalkoxy, sulphoalkoxy or carboxyalkylcarbonyloxyalkyl radical or a carboxylic acid or sulphonic acid group and R.sub.5 is a hydrogen or halogen atom, with the proviso that compounds of general formula (IIa) always contain at least one carboxylic or sulphonic acid group; and the nontoxic inorganic and organic salts of those compounds containing at least one carboxylic acid or sulphonic acid group.
The present invention also provides a process for the preparation of these chalcone derivatives, as well as pharmaceutical compositions containing them.

REFERENCES:
Baker, S. et al., J. Chem. Soc. Perkins Trans. 1(1), 178-81, 1981.
Aust. J. Chem. 32(7), 1601-12, 1979.
Kolsaker, P. et al., Tetrahedron 29(8), 1095-100, 1973.
Gaurmelon, C. et al., Bull. Soc. Chim. Fr. (7-8,PE 2) 1639-45, 1975.
Gupta, A. et al., Indian J. Chem. Soc. Sec. B 14(B)11, 903-4, 1976.

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