CGRP receptor antagonists

Details CGRP receptor antagonists CGRP receptor antagonists

2005-10-18

2010-06-29

Kifle, Bruck (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S599000

Reexamination Certificate

active

07745427

ABSTRACT:
The present invention is directed to compounds of Formula (I) and Formula (II) (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.

REFERENCES:
patent: 5635510 (1997-06-01), Burkholder
patent: 00/18764 (2000-04-01), None
patent: 03/104236 (2003-12-01), None
patent: 2004/055016 (2004-07-01), None
patent: WO 2004/092166 (2004-10-01), None
patent: 2005/035524 (2005-04-01), None
Supplementary European Search Report, Oct. 26, 2009.
Anthony E. Lanzilotti, et al., “Stereoselective reduction of some indoles with triethylsilane-trifluoroacetic acid”, Journal of Organic Chemistry, American Chemical Society, Easton, US. vol. 44, No. 26, Jul. 1, 1979, pp. 4809-4813.

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