Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-03-22
2011-03-22
Anderson, Rebecca L (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S256000, C514S365000, C514S376000, C544S242000, C544S336000, C546S271400, C548S202000, C548S230000
Reexamination Certificate
active
07910592
ABSTRACT:
Compounds having the structure of Formula (I), including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compounds of Formula (I), B is a cyclic group other than phenyl, and B has a cyclic substituent at a position that is ortho to the position at which B is connected to the remainder of the structure of Formula (I). The 5-membered ring of Formula (I) has a second cyclic substituent in addition to B.
REFERENCES:
patent: 4797130 (1989-01-01), Clausen et al.
patent: 5378724 (1995-01-01), Uhr et al.
patent: 6395732 (2002-05-01), Zimmermann et al.
patent: 6451830 (2002-09-01), Sikorski et al.
patent: 6653476 (2003-11-01), Yasuma et al.
patent: 2006/0040999 (2006-02-01), Ali et al.
patent: 0 605 729 (1994-07-01), None
patent: 1 188 747 (2002-03-01), None
patent: WO 03/031435 (2003-04-01), None
patent: WO 2005/085241 (2005-09-01), None
McKay et al.: “Cyclizations of B-Chloroethyl Substituted Ammonocarbonic Acids”, Journal of Organic Chemistry, vol. 16, No. 11, 1951, pp. 1829-1834.
Cutugno et al.: “The Reaction of beta-Amino Alcohols with 1,1-Carbonyldiimidazole-Influence of the Nitrogen Substituent on the Reaction Course”, European Journal of Organic Chemistry, vol. 3, 2001, pp. 517-522.
Supplementary European Search Report for EP 06 84 9230; Performed in Munich; Completed Jul. 30, 2010.
Ali Amjad
Chen Yi-Heng
Li Hong
Lu Zhijian
Sinclair Peter J.
Anderson Rebecca L
Daniel Mark R.
McGinnis James L.
Merck Sharp & Dohme Corp.
Shterengarts Samantha L
LandOfFree
CETP inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with CETP inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and CETP inhibitors will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2693246