CETP inhibitor polypeptide antibodies against the synthetic poly

Details CETP inhibitor polypeptide antibodies against the synthetic poly CETP inhibitor polypeptide antibodies against the synthetic poly

1995-02-24

1996-05-21

Warden, Jill

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

5303871, A61K 3816, C07K 1600

Patent

active

055190014

ABSTRACT:
A polypeptide and analogues thereof inhibit cholesteryl ester transfer protein (CETP). An anti-atherosclerosis composition comprises an anti-atherosclerosis effective amount of the polypeptide and a pharmaceutically-acceptable carrier. An anti-atherosclerosis kit comprises in separate sterile containers at least one unit of the composition containing the polypeptide, one syringe and one needle. An antibody has specificity for the polypeptide of the invention, the baboon CETP 4 kD polypeptide inhibitor, the 1-36 amino acid N-terminal fragment of apo C-I, modified apo A-I (MW: 31 kD) or modified apo E (MW: 41 kD). A method of preventing atherosclerosis in a mammal being predisposed to that condition comprises administering to the mammal a prophylactically effective amount of the polypeptide of the invention, and a method of treating a mammal afflicted with atherosclerosis comprises the administration of a therapeutically effective amount of the polypeptide disclosed herein.

REFERENCES:
Koizumi et al., "Atherosclerosis", 58:175-186 (1985).
Yokoyama et al., "Artery" 14(1):43-51 (1986).
Kushwaha et al., "J. of Lipid Research", 31:965-973 (1990).
Son et al., "Biochimica et Biophysica Acta", 795:473-480 (1984).
Kurasawa et al., "J. Biochem." 98:1499-1508 (1985).
Albers et al., "Lipids", 9:15-26 (1974).
Kohler et al., "Nature", 256:495-497 (1975).
Williams et al., "J. of Chromatography", 308:101-109 (1984).
Kushwaha et al., "J. of Lipid Research", 27:497-507 (1986).
McGill et al., "Arteriosclerosis", 6:651-663 (1986).
Redgrave et al., "Analytical Biochem.", 65:42-49 (1975).
Allain et al., "Clin. Chem.", 20:470-475 (1974).
Laemmli "Nature", 227:680-684 (1970).
Floren et al., "Metabolism", 30:367-375 (1981).
McKinney et al., "J. of Immunological Methods", 96:271-278 (1987).
Cheung et al., "J. of Lipid Research", 23:748-753 (1982).
Barany et al., "The Peptides" 2:1-284 (1980).
Duncan, D. B., "Biometrics", pp. 1-42 (1955).
Pearson et al., "Proc. Natl. Acad. Sci." 85:2444-2448 (1988).
Krul et al., J. Lip Res., 28:818, 1987, Expression . . . lipoproteins.
Lerner et al, Adv. Immunol., 36:1, 1984, Antibodies . . . medicine.
Harlow et al., Antibodies, A Laboratory Manual, 1988, p. 287.

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