Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Testing efficacy or toxicity of a compound or composition
Reexamination Certificate
2007-05-15
2007-05-15
Priebe, Scott D. (Department: 1633)
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Testing efficacy or toxicity of a compound or composition
C424S009100, C800S008000
Reexamination Certificate
active
11033003
ABSTRACT:
The invention features substantially pure nucleic acid sequences encoding wild-type or mutant serotonin reuptake transporter (SERT) polypeptides, as well as the polypeptides themselves. The invention also features methods for identifying modulators of the biological activity of a SERT and for identifying if such a modulator has a secondary target. In addition, the invention features methods for treating a condition in a subject.
REFERENCES:
patent: 5583008 (1996-12-01), Johnson et al.
patent: 6841145 (2005-01-01), Horvitz et al.
All et al., “Ionotropic and Metabotropic Activation of a Neuronal Chloride Channel by Serotonin and Dopamine in the LeechHirudo medicinalis,” J. Physiol. 509:211-219 (1998).
Blakely et al., “Cloning and Expression of a Functional Serotonin Transporter from Rat Brain,”Nature354:66-70 (1991).
Choy and Thomas, “Fluoxetine-Resistant Mutants inC. elegansDefine a Novel Family of Transmembrane Proteins,”Mol. Cell. 4:143-152 (1999).
Corey et al., “A Cocaine-SensitiveDrosophilaSerotonin Transporter: Cloning, Expression, and Electrophysiological Characterization,”Proc. Natl. Acad. Sci. USA91:1188-1192 (1994).
de Montigny and Aghajanian, “Tricyclic Antidepressants: Long-Term Treatment Increases Responsively of Rat Forebrain Neurons to Serotonin,”Science202:1303-1306 (1978).
Demchyshyn et al., “Cloning, Expression, and Localization of a Chloride-Facilitated, Cocaine-Sensitive Serotonin Transporter fromDrosophila melanogaster,” Proc. Natl. Acad. Sci. USA91:5158-5162 (1994).
Desai et al., “A Genetic Pathway for the Development of theCaenorhabditis elegansHSN Motor Neurons,”Nature336:638-646 (1988).
Gamer et al., “Serotonin Activates Cl Channels in the Apical Membrane of Rat Choroid Plexus Epithelial Cells,”Eur. J. Pharmacol. 239:31-37 (1993).
Hamdan et al., “Characterization of a Novel Serotonin Receptor fromCaenohabditis elegans: Cloning and Expression of Two Splice Variants,”J. Neurochem. 72:1372-1383 (1999).
Horvitz et al., “Serotonin and Octopamine in the NematodeCaenohabditis elegans,” Science216:1012-1014 (1982).
Huang et al., “Alternative-Splicing of Serotonin Receptor Isoforms in the Pharynx and Muscle of the Parasitic Nematode,Ascaris suum,” Mol. Biochem. Parasitol. 101:95-106 (1999).
Hung et al., “Regulation of Mouse Choroid Plexus Apical Cl−and K+Channels by Serotonin,”Brain Res. 617:285-295 (1993).
Koumenis et al., “Identification of Three Proteins in the Eye ofAplysia, Whose Synthesis is Altered by Serotonin (5-HT). Possible Involvement of these Proteins in the Ocular Circadian System,”Journal of Biological Chemistry270:14619-14627 (1995).
Lessmann and Dietzel, “Development of Serotonin-Induced Ion Currents in Identified Embryonic Retzius Cells from the Medicinal Leech (Hirudo medicinalis),”J. Neurosci. 11:800-809 (1991).
Lessmann et al., “Two Kinetically Distinct 5-Hydroxytryptamine-Activated Cl−Conductances at Retzius P-Cell Synapses of the Medicinal Leech,”J. Neurosci. 15:1496-1505 (1995).
Liu et al., “High-Throughput Isolation ofCaenorhabditis elegansDeletion Mutants,”Genome Res. 9:859-867 (1999).
Madison et al., “Phorbol Esters Block a Voltage-Sensitive Chloride Current in Hippocampal Pyramidal Cells,”Nature321:695-697 (1986).
Mendel et al., “Participation of the Protein G0in Multiple Aspects of Behavior inC. elegans,” Science267:1652-1655 (1995).
Munsch and Schlue, “Intracellular Chloride Activity and the Effect of 5-Hydroxytrypamine on the Chloride Conductance of Leech Retzius Neurons,”Eur. J. Neurosci. 5:1551-1557 (1993).
Olde and McCombie, “Molecular Cloning and Functional Expression of a Serotonin Receptor fromCaenohabditis elegans,” J. Mol. Neurosci. 8:53-62 (1997).
Parra et al., “How Many Subtypes of Inhibitory Cells in the Hippocampus?”Neuron20:983-993 (1998).
Ramamoorthy et al., “Antidepressant- and Cocaine-Sensitive Human Serotonin Transporter: Molecular Cloning, Expression, and Chromosomal Localization,”Proc. Natl. Acad. Sci. USA90:2542-2546 (1993).
Ranganathan and Horvitz, “mod-1 andmod-5, Two Genes Involved in the Serotonin-Mediated Experience-Dependent Modulation of Locomotion,” East CoastC. elegansMeeting, Boston, MA, Jun. 6-8 (1998) (Abstract).
Ranganathan et al., “An Ionotrophic Serotonin Receptor and a Serotonin Reuptake Transporter are Involved in Experience-Dependent Modulation of Behavior,” Twelfth InternationalC. elegansMeeting, Madison, WI, Jun. 2-6 (1999) (Abstract).
Ranganathan et al., “MOD-1 is a Serotonin-Gated Chloride Channel that Modulates Locomotory Behaviour inC. elegans,” Nature408:470-475 (2000).
Sawin, “Genetic and Cellular Analysis of Modulated Behaviors inCaenorhabditis elegans,” Massachusetts Institute of Technology, Ph.D. Thesis (1996).
Sawin et al., “C. elegansLocomotory Rate is Modulated by the Environment through a Dopaminergic Pathway and by Experience Through a Serotonergic Pathway,”Neuron26:619-631 (2000).
Scrogin et al., “Multiple Receptor Subtypes Mediate the Effects of Serotonin on Rat Subfomical Organ Neurons,”Am. J. Physiol. 275:R2035-R2042 (1998).
Ségalat et al., “Modulation of Serotonin-Controlled Behaviors by G0inCaenorhabditis elegans,” Science267:1648-1651 (1995).
Sze et al., “Food and Metabolic Signalling Defects in aCaenorhabditis elegansSerotonin-Synthesis Mutant,”Nature403:560-564 (2000).
Trim et al., “Characterization of 5-HT Receptors in the Parasitic Nematode,Ascaris suum,” Parasitology122:207-217 (2001).
Weinshenker et al., “Genetic and Pharmacological Analysis of Neurotransmitters Controlling Egg Laying inC. elegans,” J. Neurosci. 15:6975-6985 (1995).
Williams et al., “Identification of a Novel 5-HTN(Nematoda) Receptor fromAscaris suumMuscle,”Comp. Biochem. Physiol. 101C:469-474 (1992).
Horvitz H. Robert
Ranganathan Rajesh
Bieker-Brady Kristina
Clark & Elbing LLP
Massachusetts Institute of Technology
Priebe Scott D.
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