Certain tricyclic and pentacyclic-hetero nitrogen rhodol dyes

Details Certain tricyclic and pentacyclic-hetero nitrogen rhodol dyes Certain tricyclic and pentacyclic-hetero nitrogen rhodol dyes

1990-04-16

1993-07-13

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 47, 546 63, 546196, 544 70, 544150, 544230, 548525, 549223, 530402, 436546, C07D22120, C07D491052, C07D41314

Patent

active

052274870

ABSTRACT:
Novel fluorescent dyes based on the rhodol structure are provided. The new reagents contain functional groups capable of forming a stable fluorescent product with functional groups typically found in biomolecules or polymers including amines, phenols, thiols, acids, aldehydes and ketones. Reactive groups in the rhodol dyes include activated esters, isothiocyanates, amines, hydrazines, halides, acids, azides, maleimides, aldehydes, alcohols, acrylamides and haloacetamides. The products are detected by their absorbance or fluorescence properties. The spectral properties of the fluorescent dyes are sufficiently similar in wavelengths and intensity to fluorescein or rhodamine derivatives as to permit use of the same equipment. The dyes, however, show less spectral sensitivity to pH in the physiological range than does fluorescein, have higher solubility in non-polar solvents and have improved photostability and quantum yields.

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L. G. Lee, et al., Cytometry 10:151-164 (1989).
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