Certain thiazole-5-carboxamide compounds

Details Certain thiazole-5-carboxamide compounds Certain thiazole-5-carboxamide compounds

1976-07-19

1977-12-20

Gallagher, R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260302R, 260302H, C07D22756

Patent

active

040641350

ABSTRACT:
Processes and intermediates for preparing 1-alkylamino-3-(5-substitutedaminocarbonylthiazol-2-yloxy)-2-propanols and 5-(5-substitutedaminocarbonylthiazol-2-yloxymethylene)-N-alkyloxazolidine and 2-substituted oxazolidine derivatives thereof and intermediates therefore. The present processes, and intermediates, reduce the number of transformations necessary to produce these products as compared with the prior processes. The products are useful to treat abnormal heart conditions and/or hypertension in mammals. The intermediates are 2-alkylsulfinyl-5-substitutedaminocarbonylthiazoles and 2-alkylsulfonyl-5-substitutedaminocarbonylthiazoles.

REFERENCES:
patent: 3230229 (1966-01-01), Hatchard
patent: 3668212 (1972-06-01), Shen et al.
patent: 3679695 (1972-07-01), Moore et al.
patent: 3888870 (1975-06-01), Jackson

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