Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-04-09
1999-05-11
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514570, 546294, 562427, 562429, A61K31/44;31/19
Patent
active
059028173
ABSTRACT:
The present invention relates to thio derivatives that inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, to treat a glutamate abnormality and to treat a prostate disease in an animal.
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Jackson Paul F.
Maclin Keith M.
Slusher Barbara S.
Tays Kevin L.
Guilford Pharmaceuticals Inc.
Juneau Todd L.
Nath Gary M.
Rotman Alan L.
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