Certain substituted polyketides, pharmaceutical compositions...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S235800, C514S237200, C514S237800, C514S238800, C514S239200, C514S239500, C514S332000, C514S333000, C514S335000, C514S336000, C514S340000, C514S344000, C514S342000, C514S343000, C514S345000, C514S352000, C514S369000, C514S371000, C514S376000, C514S377000, C514S380000, C514S382000, C514S397000, C514S398000, C514S444000, C514S445000, C514S447000, C514S478000, C514S481000, C514S485000, C514S488000, C544S101000, C544S111000, C544S124000, C544S132000, C544S133000, C544S145000, C544S171000, C546S268400, C546S

Reexamination Certificate

active

06972292

ABSTRACT:
The present invention relates to certain substituted polyketides of formula I,wherein A, B, C, D, E, F and m are as defined herein, pharmaceutical compositions containing said compounds, and the use of said compounds in treating tumors.

REFERENCES:
patent: 6096904 (2000-08-01), Smith, III et al.
patent: 6127406 (2000-10-01), Gunasekera et al.
patent: WO 98/24429 (1998-06-01), None
patent: WO 00/04865 (2000-02-01), None
patent: WO 02/46150 (2002-06-01), None
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Hung D.T. et al., “Syntheses of Discodermolides Useful for Investigating Microtubule Binding and Stabilization”, J.Am.Chem.Soc., vol. 118, No. 45, pp. 11054-11080 (1996).
Paterson I. et al., “Total Synthesis of the Antimocrotubule Agent . . . Aldol Reactions of Chiral Ketones”, Angew.Chem.Int.Ed., vol. 39, No. 2, pp. 377-380 (2000).
Curran D.P. et al., “Simultaneous Preparation of Four Truncated Analogues . . . Fluorous Mixture Synthesis”, Organic Letters, vol. 4, No. 13, pp. 2233-2235 (2002).
Abstract, 01694771, Halstead, David Patrick, vol. 60/03-B of Dissertation Abstracts International, p. 1087.

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