Certain substituted 1-aryl-3-piperazine-1′-yl propanones

Details Certain substituted 1-aryl-3-piperazine-1′-yl propanones Certain substituted 1-aryl-3-piperazine-1′-yl propanones

2007-02-06

2007-02-06

Stockton, Laura L. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

active

10304468

ABSTRACT:
Disclosed are compounds of formula I:whereinX is a carbonyl, sulfonyl, methylene, or methylene substituted with optionally substituted phenyl;Z is nitrogen or CH;Ar1and Ar2independently represent aryl groups; andY is hydrogen; orY and R1or R2together represent CH2; CH2CH2; CH2O; CH2S forming a five or six membered ring and such ring may be optionally substituted with loweralkyl or phenyl; or the pharmaceutically acceptable salts thereof, useful in the treatment of neoplastic diseases, and bacterial or fungal infections, and in preventing or decreasing the production of abnormally phosphorylated paired helical filament (PHF) epitopes associated with Alzheimer's Disease and, therefore, useful for treating Alzheimer's Disease.

REFERENCES:
patent: 3439035 (1969-04-01), Grisar et al.
patent: 3491093 (1970-01-01), Pachter et al.
patent: 3576803 (1971-04-01), Moon
patent: 4745191 (1988-05-01), Husbands
patent: 5338857 (1994-08-01), Ohto et al.
patent: 5466691 (1995-11-01), Nakao et al.
patent: 5693804 (1997-12-01), DeBernardis et al.
patent: 2 360 545 (1974-06-01), None
patent: 193875 (1986-09-01), None
patent: 0 296 560 (1988-12-01), None
patent: 0 414 391 (1991-02-01), None
patent: 0 648 744 (1995-04-01), None
patent: 2 488 893 (1982-02-01), None
patent: WO-93/03025 (1993-02-01), None
Natova et al. (1981), “Synthesis and Structures of Some Mannich Bases containing Five-Membered Heterocyles,”God. Vissh. Khim,-Tekhnol. Inst.. Sofia. vol. 24. No. 4. pp. 47-56.
Shi et al.(1987), “Synthesis of New Cerebral Vasodilator”Chemical Abstracts, vol. 106, No. 13, Abstract No. 102232.b, p. 654.
Ohtaka et al. (1987), “Benzylpiprazine Derivatives. I., Syntheses and Biological Activities 1-(2,3,4-Trimethoxybenzyl)piperazine Derivatives”Chem. Pharm. Bull., vol. 35, No. 7, pp. 2774-2781.
Ohtaka et al. (1987), “Benzylpiperazine Derivatives. II., Syntheses and Cerebral Vasodilating Activities of 1-[(3-Alkyl-3-hydroxy-3-phenyl)propyl]-4-benzylpiperazine Derivatives”Chem. Pharm. Bull., vol. 35, No. 7, pp. 2782-2791.
Database WPI, Week 8032, Derwent Publication Ltd.,London, GB; AN 80-55940C and JP,A,55 083 772 (Kanebo K. K.) Jun. 25, 1980.
Dimmock et al., (1989), “Evaluation of the cytoxicity of som Mannich bases of acetophenone against the EMP6 tumour”,Pharmazie, 45 (1990), H. 10, pp. 755-757.
Dimmock et al., “Syntheses and Evaluation of Some Mannich Bases Derived from Acetophenones Against P388 Lymphcytic Leukemia and Toxicologica Assessment of 3-Dimethyl-amino-2-dimethylaminoamethyl-1(-4-methoxphenyl)-1-Propanon Dihydrochloride in Rats”,Journal of Pharmaceutical Sciences, vol. 73, No. 4, Apr. (1984), pp. 471-477.
Valenta et al., “1-[3-(2-Alkoxyphenoxy)-3-Phenylpropyl]Piperazines and Some Related Compounds”,Collection, Czechoslovak Chem. Commun., vol. 46, 1981.

Affiliated with

Also associated with

Rating

Certain substituted 1-aryl-3-piperazine-1′-yl propanones does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Certain substituted 1-aryl-3-piperazine-1′-yl propanones, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Certain substituted 1-aryl-3-piperazine-1′-yl propanones will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3884869