Certain ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives in

Details Certain ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives in Certain ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives in

1986-01-08

1987-03-03

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514256, 514273, 514275, 544310, 544317, 544320, 544321, 544322, 544327, 544328, 544331, 546 15, 546 64, 546 82, 546 83, A61K 3144, C07D47104

Patent

active

046475664

ABSTRACT:
Compounds of the formula formula IA or IB ##STR1## wherein A represents an optionally substituted saturated divalent grouping which together with the two carbon atoms to which it is attached represents a fused 5-, 6- or 7-membered carbocyclic or heterocyclic ring selected from optionally substituted fused cyclopenteno, cyclohexeno, cyclohepteno, dihydrothieno, dihydrothiopyrano, tetrahydrothiepino, dihydrofuro, dihydropyrano, tetrahydrooxepino, dihydropyrrolo, tetrahydropyrido and tetrahydroazepino; R.sub.1 represents lower alkyl, phenyl, or phenyl mono- or disubstituted by lower alkyl, lower alkoxy, halogen or trifluoromethyl; or R.sub.1 represents an aromatic heterocyclic radical selected from e.g. optionally substituted pyridyl, quinolyl, isoquinolyl, pyrimidyl and thiazolyl; R.sub.2, R.sub.3, R.sub.3 ' are hydrogen or lower alkyl; and pharmaceutically acceptable salts; are useful as benzodiazepine receptor modulators for the treatment of nervous system disorders. Pharmaceutical compositions, methods of preparation and certain intermediates useful as benzodiazepine receptor modulators are also disclosed.

REFERENCES:
patent: 4312870 (1982-01-01), Yokoyama
patent: 4479955 (1984-10-01), Yokoyama

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