Certain ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives

Details Certain ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives Certain ring-fused pyrazolo[3,4-d]-pyridin-3-one derivatives

1988-01-25

1989-03-21

Schwartz, Richard A.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 15, 546 64, C07D47104

Patent

active

048144509

ABSTRACT:
Compounds of the formula formula IA or IB ##STR1## wherein A represent an optionally substituted saturated divalent grouping which together with the two carbon atoms to which it is attached represents a fused 5-, 6- or 7-membered carbocyclic or heterocyclic ring selected from optionally substituted fused cyclopenteno, cyclohexeno, cyclohepteno, dihydrothieno, dihydrothiopyrano, tetrahydrothiepino, dihydrofuro, dihydropyrano, tetrahydrooxepino, dihydropyrrolo, tetrahydropyrido and tetrahydroazepino; R.sub.1 represents lower alkyl, phenyl, or phenyl mono- or disubstituted by lower alkyl, lower alkoxy, halogen or trifluoromethyl; or R.sub.1 represents an aromatic heterocyclic radical selected from e.g. optionally substituted pyridyl, quinolyl, isoquinolyl, pyrimidyl and thiazolyl; R.sub.2, R.sub.3, R.sub.4 ' are hydrogen or lower alkyl; and pharmaceutically acceptable salts; are useful as benzodiazepine receptor modulators for the treatment of nervous system disorders. Pharmaceutical compositions, methods of preparation and certain intermediates useful as benzodiazepine receptor modulators are also disclosed.

REFERENCES:
patent: 4602014 (1986-07-01), Yokoyama
patent: 4647566 (1987-03-01), Yokoyama
patent: 4690930 (1987-09-01), Takada et al.
patent: 4740512 (1988-04-01), Yokoyama

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