Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-04-08
1996-01-23
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546261, 546291, 546292, 514346, A61K 3144, C07D40112, C07D21184, C07D21381
Patent
active
054865298
ABSTRACT:
The present invention relates to certain novel heterocyclic ketones which are 1-pyridylacetamide ketones of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic ketones, processes for preparing the heterocyclic ketones, pharmaceutical compositions containing such heterocyclic ketones and methods for their use.
REFERENCES:
patent: 4880780 (1989-11-01), Trainor et al.
patent: 4910190 (1990-03-01), Bergeson et al.
Bernstein Peter R.
Shaw Andrew
Thomas Royston M.
Veale Chris A.
Warner Peter
Alexander Michael D.
Harris Robert J.
Newtson Ruth H.
Rotman Alan L.
Zeneca Limited
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