Certain pyridyl hydrazines and hydrazides useful for protein lab

Details Certain pyridyl hydrazines and hydrazides useful for protein lab Certain pyridyl hydrazines and hydrazides useful for protein lab

1992-05-26

1993-04-27

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544238, 548190, 548545, 548548, 5303915, C07D40102, C07D40302

Patent

active

052063704

ABSTRACT:
Bifunctional aromatic compounds which are capable of linking metal ions to biologically useful molecules. The bifunctional compounds are characterized as having a hydrazine or hydrazide group and a protein reactive group. The hydrazine or hydrazide group may be protected as a lower alkyl hydrazone. Conjugates of the bifunctional compounds with macromolecules are also described and labelled macromolecules comprised of the conjugates and metal ions are provided. Additionally, a method is provided for forming a labelled macromolecule by reacting a conjugate with a metal species The compounds and method of this invention are particularly useful in the fields of biology and medicine for imaging and/or therapy.

REFERENCES:
patent: 4861869 (1989-08-01), Nicolotti et al.

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