Certain pyrazole derivatives as cortiocotropin-releasing factor

Details Certain pyrazole derivatives as cortiocotropin-releasing factor Certain pyrazole derivatives as cortiocotropin-releasing factor

1999-08-05

2000-10-03

Ramsuer, Robert

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5483741, A61K 31415, A61P 2524, C07D23114

Patent

active

061273996

ABSTRACT:
Disclosed are compounds that are highly selective partial agonists or antagonists at human CRF.sub.1 receptors that are useful in the diagnosis and treatment of treating stress related disorders such as post traumatic stress disorder (PTSD) as well as depression, headache and anxiety. The compounds have the formula ##STR1## or the pharmaceutically acceptable salts thereof wherein Ar, R.sub.1, R.sub.2, A, and Z are various organic and inorganic substituents.

REFERENCES:
patent: 5760225 (1998-06-01), Yuan
patent: 5973152 (1999-10-01), Yuan

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