Certain pyrazole derivatives as corticotropin-releasing factor r

Details Certain pyrazole derivatives as corticotropin-releasing factor r Certain pyrazole derivatives as corticotropin-releasing factor r

1996-11-15

1998-06-02

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544371, 546146, 546148, 546211, 5483741, 5483751, C07D40106, C07D41306

Patent

active

057602255

ABSTRACT:
Disclosed are compounds that are highly selective partial agonists or antagonists at human CRF.sub.1 receptors that are useful in the diagnosis and treatment of treating stress related disorders such as post traumatic stress disorder (PTSD) as well as depression, headache and anxiety. The compounds have the formula ##STR1## or the pharmaceutically acceptable salts thereof wherein Ar, R.sub.1, R.sub.2, A, and Z are various organic and inorganic substituents.

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