Certain phosphonic acids and derivatives useful for the treatmen

Details Certain phosphonic acids and derivatives useful for the treatmen Certain phosphonic acids and derivatives useful for the treatmen

1989-11-27

1991-10-15

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

548413, 546 22, 546 23, C07F 9572, A61K 3140

Patent

active

050575066

ABSTRACT:
The present invention is concerned with the phosphonic acids of formula I ##STR1## wherein one or both of the acidic hydroxy groups of the phosphonic acid moiety may be functionalized in form of pharmaceutically acceptable mono- or di- esters; wherein Y represent optionally substituted 2-carboxypyrrolidinyl, 2-carboxy-2,5-dihydropyrrolyl, 2-carboxy-1,2,3,6-tetrahydropyridinyl, 2-carboxy-1,2,5,6-tetrahydropyridinyl, 2-carboxypiperidinyl, 2-carboxyetrahydroquinolinyl or 2-carboxyperhydroquinolinyl, 2-carboxyl-2,3-dihydroindolyl or 2-carboxyperhydroindolyl as described herein, and in each of which the carboxy group may be functionalized in form of a pharmaceutical acceptable ester or amide; A represents a direct bond, lower alkenylene, lower alkylidene or lower alkylene provided that A does not represent a direct bond when Y represents 2-carboxypyrolidinyl; and pharmaceutically acceptable salts thereof; which are useful for the treatment of nervous system disorders in mammals and as antagonists of the N-methyl-D-aspartate sensitive excitatory amino acid receptor.

REFERENCES:
patent: 4898854 (1990-02-01), Hutchison et al.
patent: 4906621 (1990-03-01), Hutchison et al.
Chem. Abstracts, vol. 104 (9), Abst. No. 104:69130-a Mar. 3, 1986.
Chem. Abstracts, vol. 108(13), Abst. No. 108: 112,734-X, Mar. 28, 1988.
Tetrahedron Letters No. 51, pp. 4929-2930 E. Petrilla Jr. and E. R. Spitz Miller.
Chem. Pharm. Bull. 32 391814 25 (1984).
Phosphorus and Sulfur 1984 vol. 20 pp. 313-321.

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