Certain phosphonic acid quinoline-2-carboxylic acids, esters or

Details Certain phosphonic acid quinoline-2-carboxylic acids, esters or Certain phosphonic acid quinoline-2-carboxylic acids, esters or

1991-07-30

1993-06-08

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

546 23, 546 22, 548413, 514 89, 514 91, C07F 960, C07F 962, A61K 3147

Patent

active

052179630

ABSTRACT:
The present invention is concerned with the phosphonic acids of formula I ##STR1## wherein one or both of the acidic hydroxy groups of the phosphonic acid moiety may be functionalized in form of pharmaceutically acceptable mono- or di- esters; wherein Y represents optionally substituted 2-carboxytetrahydroquinolinyl or 2-carboxyperhydroquinolinyl, and in each of which the carboxy group may be functionalized in form of a pharmaceutically acceptable ester or amide; A represents a direct bond, lower alkenylene, lower alkylidene or lower alkylene; and pharmaceutically acceptable salts thereof; which are useful for the treatment of nervous system disorders in mammals and as antagonists of the N-methyl-D-aspartate sensitive excitatory amino acid receptor.

REFERENCES:
patent: 4477391 (1984-10-01), Collins
patent: 4483853 (1984-11-01), Collins et al.
patent: 4705781 (1987-11-01), Boast
patent: 4746653 (1988-05-01), Hutchison et al.
patent: 4906621 (1990-03-01), Hutchison et al.
patent: 5057506 (1991-10-01), Hutchison et al.
Park et al., Agric. Biol. Chem. vol. 41 No. 3 pp. 573-579 (1977).
Park et al., Agr. Biol. Chem. vol. 40 No. 9 pp. 1905-1906 (1976).
Kleirok et al., Pol. J. Pharmacol. Pharm. vol. 37 pp. 575-584 (1985).
Meldrum, Epilepsia, vol. 25 (Suppl. 2) pp. 5140-5149 (1984).
Croucher, Neuropharmacology vol. 23 No. 4 pp. 467-472 (1984).
Petrillo, Jr., Tetrahedron Letters No. 51 pp. 4929-4930 (1979).
Petrillo, Jr., Medicinal Research Reviews vol. 2 No. 1 pp. 1.varies.41 (1982).
O'Leary et al., Biochemistry vol. 19 pp. 3400-3406 (1980).
Matoba, Chem. Pharma. Bull. vol. 32 No. 10 pp. 3918-3925 (1984).

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