Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1987-09-10
1990-09-04
Rotman, Alan L.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546281, 546294, C07D207452
Patent
active
049546376
ABSTRACT:
Coupling of biological materials is disclosed via 4-hydroxy-3-nitrobenzene sulfonic acid sodium salt (HNSA) esters. The novel activated esters are structured so as to react at one end with an amine group of a selected biological or non-biological material, thereby releasing the spectroscopically monitorable HNSA dianion, and at the other end with, typically, a sulfhydryl group of a second material which may or may not be biological. The esters provide for a cross-linking reaction that may be easily controlled and monitored.
REFERENCES:
patent: 4046636 (1977-09-01), Ullman et al.
patent: 4214048 (1980-07-01), Kitagawa
patent: 4253844 (1981-03-01), Linet
patent: 4253996 (1981-03-01), Katz
patent: 4323647 (1982-04-01), Monji et al.
patent: 4334069 (1982-06-01), Buckler et al.
patent: 4487715 (1984-12-01), Nitecki et al.
patent: 4517303 (1985-05-01), Freytag
Kitagawa et al., (1976) J. Biochem. 79:233-236.
Yoshitake et al., (1979) Eur. J. Biochem. 101:395-399.
Rector et al., (1978) J. Immunol. Methods 24: 321-336.
Carlsson et al., (1978) Biochem. J. 173:723-737.
Pain et al., (1981) J. Immunol. Methods 40:219-230.
Gershkovich et al., (1978) Bioorganicheskaya Khimiya 4:1129-1131.
Gershkovich et al., (1979) Bioorganicheskaya Khimiya 5:1125-1131.
Gershkovich et al., (1982) Bioorganicheskaya Khimiya 8:1486-1489.
Bhatnagar et al., in Peptides: Synthesis-Structure Functon, ed. by D. Rich et al., (Rockford: Pierce Chemical Company, 1981), pp. 97-100.
Nitecki et al., in High Technology Route to Virus Vaccines (ed. by Dreesman et al. 1985) pp. 43-45.
Klausner, "Peptides" edited Goodman & Meienhofer, John Wiley (1977), pp. 536-538.
Bodanszky, J. Org. Chem. 38(7), pp. 1296-1300 (1973).
Aldwin Lois
Nitecki Danute E.
Cetus Corporation
Giotta Gregory J.
Halluin Albert P.
Reed Dianne E.
Rotman Alan L.
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