Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-05-04
1988-10-04
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514382, 514422, 514443, 514444, 514469, 548251, 548252, 548253, 548336, 548525, 549 57, 549 51, 549 58, 549 60, 549463, 549470, 549471, A61K 31415, C07D40506
Patent
active
047756799
ABSTRACT:
Phenylalkyl-2,3-dihydrobenzofurans and analogs were prepared by (1) nucleophilic substitution involving an appropriately substituted 2,3-dihydrobenzofuranol (or 2,3-dihydrobenzopyranol) and a cinnamylhalide followed by reduction; or (2) by Wittig reaction involving a halomethyl derivative of 2,3-dihydrobenzofuran (or 2,3-dihydrobenzopyran and an aryl or a heteroaryl aldehyde followed by reduction. These compounds were found to be potent anti-inflammatory agents.
REFERENCES:
patent: 4490531 (1984-12-01), Johnson
patent: 4495357 (1985-01-01), Johnson
Boulton David A.
Chang Michael N.
Thompson Kathryn L.
Cheng Theresa Y.
Dentz Bernard I.
Lee Mary C.
Merck & Co. , Inc.
Sudol Michael C.
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