Certain glyceryl phosphate-cyclic ammonium compounds useful for

Details Certain glyceryl phosphate-cyclic ammonium compounds useful for Certain glyceryl phosphate-cyclic ammonium compounds useful for

1989-11-22

1991-10-01

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 89, 514 91, 540450, 540542, 546 25, 548413, C07F 959, C07F 938, C07F 9553, A61K 31675

Patent

active

050534025

ABSTRACT:
A glycerol derivative which is effective to reduce blood pressure and has the formula: ##STR1## wherein R.sup.1 is an alkyl group having 10-22 carbon atoms, R.sup.2 is a lower acyl group or benzoyl, each of R.sup.3 and R.sup.4 independently is hydrogen or a straight or branched chain alkyl group having 1-6 carbon atoms; each of R.sup.5, R.sup.6 and R.sup.7 independently is hydrogen, a straight or branched chain alkyl group having 1-6 carbon atoms, an aryl group or an aralkyl group; and each of m and n independently is 0 or a positive integer under the condition of m+n=2-8.

REFERENCES:
patent: 4710579 (1987-12-01), Nojima et al.
LIPIDS, vol. 3, No. 3, 1968, pp. 228-233; D. L. Turner et al.: "The Total Synthesis of Phosphatidyl(Dioleoyl)Hydroxy-L-Proline and its Activity in Blood-Clotting Systems".
European Journal of Pharmacology, vol. 131, 1986, pp. 179-188, Elsevier Science Publishers B.V.; E. Coeffier et al.: "Effects of PAF-Acether Structural Analogues on Platelet Activation and Bronchoconstriction in Guinea-Pigs".
"Chemical Abstracts" 84:58255n.
"Chemical Abstracts" 51,210c.

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