Certain glycerol-phosphoryl choline derivatives, compositions co

Details Certain glycerol-phosphoryl choline derivatives, compositions co Certain glycerol-phosphoryl choline derivatives, compositions co

1982-06-24

1985-01-15

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant virus encoding one or more heterologous proteins...

260941, 546 22, 424200, C07F 9141, C07F 9143, A61K 31685

Patent

active

044938322

ABSTRACT:
New phospholipid derivatives represented by the formula: ##STR1## wherein R.sup.1 is alkyl, alkoxy, alkylthio, ar(lower)alkoxy or alkanoylamino; R.sup.2 is lower alkyl or ar(lower)alkyl; n is an integer of 0 or 1; A is lower alkylene; R.sup.3 is pyridinio or a group of the formula: ##STR2## in which R.sup.5, R.sup.6 and R.sup.7 are each hydrogen or lower alkyl; and R.sup.4 is hydrogen or lower alkyl; and pharmaceutically acceptable salt thereof, which exhibit anti-hypertensive activity.

REFERENCES:
patent: 3542820 (1970-11-01), Rakhit
patent: 3577446 (1971-05-01), Rakhit
Orchin et al., "The Vocabulary of Organic Chemistry", pp. 469, Wiley-Interscience, 1980.
Chemical Abstracts, vol. 93, No. 3, 21st Jul. 1980, pp. 653, 25917n.
Chemical Abstracts, vol. 88, No. 7, 13th Feb. 1978, pp. 559, No. 50965f, Robinson et al., "Phosphonolipids XXVII, Synthesis of Phosphonic Acid Analogs of Saturated and Unsaturated L-alpha-lecithins", and Can. J. Biochem., 1977, 55(8), 907-910.

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