Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2005-12-20
2005-12-20
Wilson, James O. (Department: 1623)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S048000, C514S051000, C536S025600, C536S026100
Reexamination Certificate
active
06977246
ABSTRACT:
The present invention relates to certain novel dinucleotides and formulations thereof which are highly selective agonists of the P2Y2and/or P2Y4purinergic receptor. They are useful in the treatment of chronic obstructive pulmonary diseases such as chronic bronchitis, PCD, cystic fibrosis, as well as prevention of pneumonia due to immobility. Furthermore, because of their general ability to clear retained mucus secretions and stimulate ciliary beat frequency, the compounds of the present invention are also useful in the treatment of sinusitis, otitis media and nasolacrimal duct obstruction. They are also useful for treatment of dry eye disease and retinal detachment as well as facilitating sputum induction and expectoration.
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McKenna,
Pendergast William
Rideout Janet L.
Siddiqi Suhaib M.
Yerxa Benjamin R.
Howrey Simon Arnold & Whirte, LLP
Inspire Pharmaceuticals Inc.
Kung Viola T.
Owens Howard V.
Wilson James O.
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