Certain decahydro-7H-benz(e)-inden-7-ones, compositions containi

Details Certain decahydro-7H-benz(e)-inden-7-ones, compositions containi Certain decahydro-7H-benz(e)-inden-7-ones, compositions containi

1982-02-19

1984-08-21

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424311, 424331, 568373, 560256, 546318, C07D21355, A61K 31455, C07C 6914, C07C 4938

Patent

active

044669712

ABSTRACT:
Novel antiandrogenic compositions comprising an antiandrogenically effective amount of at least one compound of the formula ##STR1## wherein R is alkyl of 1 to 4 carbon atoms, R.sub.1 is alkyl of 1 to 2 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms optionally interrupted with a heteroatom, alkenyl and alkynyl of 2 to 8 carbon atoms optionally interrupted with a heteroatom, formyl and acyl of an organic carboxylic acid of 2 to 18 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.4 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, the dotted lines indicate optional presence of a double bond between the 4(5) and 5a(6) carbons and the wavy line indicates that R.sub.4 may be in the .alpha.-or .beta.-position and a non-toxic, pharmaceutical carrier or excipient and a method of treating hyperandrogenic conditions in warm-blooded animals.

REFERENCES:
patent: 3496199 (1970-02-01), Uskokovic
patent: 3499912 (1970-03-01), Uskokovic et al.
patent: 3956316 (1976-05-01), Uskokovic et al.

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