Certain cycloalkyl imidazopyrimides, a new class of gaba brain r

Details Certain cycloalkyl imidazopyrimides, a new class of gaba brain r Certain cycloalkyl imidazopyrimides, a new class of gaba brain r

1997-12-09

2000-01-11

Bernhardt, Emily

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544115, C07D48704

Patent

active

060137991

ABSTRACT:
Disclosed are compounds of the formula: ##STR1## or pharmaceutically acceptable non-toxic salts thereof wherein: R.sub.9 and Y are substituents as defined herein; and
R.sub.a and R.sub.b independently represent halogen, hydroxy, amino, mono or dialkylamino where each alkyl is straight or branched chain alkyl having 1-6 carbon atoms, straight or branched chain lower alkyl having 1-6 carbon atoms, or straight or branched chain lower alkoxy having 1-6 carbon atoms,
which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine type drugs, and enhancement of alertness.

REFERENCES:
patent: 5185446 (1993-02-01), Shaw et al.
patent: 5426186 (1995-06-01), Shaw et al.
patent: 5696260 (1997-12-01), Shaw et al.

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