Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-06-03
1994-03-22
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514 63, 546 14, 546269, C07D40704, C07F 702, A61K 3144, A61K 31695
Patent
active
052964922
ABSTRACT:
A chroman derivative represented by the following general formula [1]: ##STR1## wherein R.sub.1 represents cyano group, nitro group, halogenomethyl group or --SO.sub.2 --X group (X represents lower alkyl group having 1-6 carbon atoms or aryl group); R.sub.2 represents hydrogen atom or OA group (A represents hydrogen atom, nitro group, lower acyl group having 1-6 carbon atoms, arylcarbonyl group, lower alkylsulfonyl group having 1-6 carbon atoms, arylsulfonyl group, arylalkyl group, tetrahydropyranyl group, lower alkoxycarbonyl group having 1-6 carbon atoms, arylalkoxycarbonyl group or silyl derivative group); R.sub.3 singly represents a hydrogen atom; or R.sub.3 forms a bond jointly with R.sub.2 ; and R.sub.4, R.sub.5, R.sub.6 and R.sub.7 each represent hydrogen atom, vinyl group, formyl group, --Y--(OA).sub.n group (Y represents straight or branched chain alkylene group having 1-6 carbon atoms or lower alkenyl group having 1-6 carbon atoms, A is as defined above, and n represents an integer of 1-3.
The compound of this invention is expected to be effectively usable as an agent for treatment of various symptoms due to the contraction of smooth muscles, for treatment of the diseases of the circulatory system and for treatment of epilepsy.
REFERENCES:
patent: 5143924 (1992-09-01), Gericke et al.
Br. J. Pharmac. (1986), 88, 103-111; T. C. Hamilton, et al.: "Comparison of the Effects of BRL 34915 and Verapamil on . . . ".
Br. J. Pharmac. (1986) 89, 395-405; S. L. Allen, et al.; "Electrical and Mechanical Effects of BrL34915 in . . . ".
Hosono Makoto
Iida Masashi
Inubushi Atsuro
Narita Kazuhisa
Sagawa Yukihiro
Nippon Kayaku Kabushiki Kaisha
Rotman Alan L.
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