Certain chemical entities, compositions and methods

Details Certain chemical entities, compositions and methods Certain chemical entities, compositions and methods

2011-08-16

2011-08-16

Seaman, D (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S118000

Reexamination Certificate

active

07998976

ABSTRACT:
Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of obesity, sarcopenia, wasting syndrome, frailty, cachexia, muscle spasm, post-surgical and post-traumatic muscle weakness, neuromuscular disease, and other indications.

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Neil et al., Endocrinology, (2009), 150(7), pp. 3207-3213.
Li et al., Nature Medicine, vol. 6(10), (2000), pp. 115-1120.

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