Certain .beta.-oxo-.alpha.-carbamoylpyrrolepropionitriles

Details Certain .beta.-oxo-.alpha.-carbamoylpyrrolepropionitriles Certain .beta.-oxo-.alpha.-carbamoylpyrrolepropionitriles

1986-02-05

1987-02-17

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548403, 548540, A61K 3140, C07D207323

Patent

active

046440100

ABSTRACT:
1-Unsubstituted .beta.-oxo-.alpha.-(phenylcarbamoyl)-.beta.-pyrrolylpropionitriles, e.g. those of the formula ##STR1## wherein R.sub.1 and R.sub.2 =H or alkyl, and R.sub.3 and R.sub.4 =H, alkyl, alkoxy, OH, halogen or CF.sub.3, are analgesic, and antiarthritic agents. Their synthesis, pharmaceutical compositions thereof, and methods of treatment utilizing such compounds are included.

REFERENCES:
patent: 4061767 (1977-12-01), Ertel et al.
patent: 4256759 (1981-03-01), Walker
patent: 4435407 (1984-03-01), Walker
Dains; J. A. C. S., 35, (1913), pp. 959-970.
Jones; Advances in Heterocyclic Chemistry, 11, pp. 383-472, (1970).

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