Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Allergen or component thereof
Patent
1978-02-09
1980-01-22
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Allergen or component thereof
424285, 26034622, 26034673, 26034673, C07D30785, A61K 3134
Patent
active
041851102
ABSTRACT:
Novel benzoheterocyclylglyoxylic acid derivatives of the formula ##STR1## in which Z is free, etherified or acylated hydroxyl, X is thio or oxy, R is free or etherified hydroxyl, R.sub.1 is lower alkyl, cycloalkyl, hydroxyl, lower alkoxy, substituted or unsubstituted phenoxy, substituted or unsubstituted amino, acyl, carboxyl, halogen, nitro or, if Z is acylated hydroxyl and/or X is oxy, hydrogen, R.sub.2 is hydrogen, lower alkyl, hydroxyl or halogen and R.sub.3 and R.sub.4 are each hydrogen or lower alkyl, or in which two adjacent radicals R.sub.1, R.sub.2, R.sub.3 and R.sub.4 together form lower alkylene having 3 to 5 chain carbon atoms or 1,4-butadienylene and the other two radicals are each hydrogen, and their pharmaceutically acceptable salts are useful as anti-allergic agents.
REFERENCES:
Dean, et al., J. Chem. Soc., 1957, pp. 3112-3117.
Fries, et al., Chem. Abstracts, 1914, pp. 3428-3429.
Mustafa, The Chemistry of Heterocyclic Compounds-Benzofurans, (vol. 29 in series), John-Wiley, 1974, p. 210.
Barton, et al., J. Chem. Soc., (1947), pp. 1574-1578.
Hart, et al., J. Chem. Soc., (1924) pp. 876-881.
Bosshard Hans
Buhler Niklaus
Eichenberger Kurt
Goschke Richard
Jaeggi Knut A.
Ciba-Geigy Corporation
Dentz Bernard
Maitner John J.
Rotman Alan L.
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