Certain benzodiimidazoles and their use as radiation sensitizers

Details Certain benzodiimidazoles and their use as radiation sensitizers Certain benzodiimidazoles and their use as radiation sensitizers

1984-06-21

1986-04-08

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514387, 514388, 514393, 514394, 514395, 548114, 548302, 548305, 548306, 548323, 548326, A61K 31675, C07D48704

Patent

active

045813493

ABSTRACT:
This invention relates to novel benzodiimidazole diols and diones and their ability to sensitize hypoxic cells to radiation, thus demonstrating utility for enhancing the treatment of solid tumors by radiation in a subject in need of such treatment.

REFERENCES:
patent: 3060188 (1962-10-01), Marxer
Chemical Abstracts, 47:12366g (1952).
[L. S. Efros, Zhur Obshchei Khim. 22, 1008-15 (1952)].
A. Marxer, Helv. Chim. Acta 44, 762-770 (1961).
E. Winkelmann, Tetrahedron, vol. 25, 2427-2454 (1969).

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