Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1977-03-09
1978-02-14
Rollins, Alton D.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260239BD, 2602393D, 260295K, 424269, C07D48704
Patent
active
040737845
ABSTRACT:
Compounds of the formula V ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 3 carbon atoms, inclusive; ##STR2## in which n is 2 or 3; and X is hydrogen, fluoro or chloro; wherein R.sub.2 is hydrogen, methyl or ethyl; wherein R.sub.3 is hydrogen, fluoro, chloro, bromo, trifluoromethyl and nitro; and wherein Ar is phenyl, o-chlorophenyl, o-fluorophenyl, 2,6-difluorophenyl or 2-pyridyl are prepared by treating a hydrazino compound of the formula: ##STR3## WHEREIN Ar, R.sub.2 and R.sub.3 are defined as above with an alkyl oxalyl chloride and cyclizing the obtained products. Compound V, including the pharmacologically acceptable acid addition salt thereof, have sedative, anxiolytic and muscle-relaxing activity and can be used for the treatment of anxieties or muscle strains of mammals, including man.
REFERENCES:
patent: 3818003 (1974-06-01), Szmuszkovicz
patent: 3882112 (1975-05-01), Szmuszkovicz
patent: 3933816 (1976-01-01), Szmuszkovicz
patent: 4016165 (1977-04-01), Moffett
patent: 4017492 (1977-04-01), Moffett
patent: 4028356 (1977-06-01), Moffett
Moffett, Letters on Heterocyclic Chemistry, vol. 3, pp. 3449-3456, (1976).
Berneis Hans L.
Rollins Alton D.
The Upjohn Company
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