Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Ester doai
Patent
1995-01-06
1996-06-25
Rotman, Alan L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Ester doai
514534, 514596, 514597, 514598, 560 19, 560 20, 560 34, 558418, 564 48, 564 49, 564 50, 564 52, 564 53, A61K 31275, C07C22948, C07C27526, C07C27528
Patent
active
055300260
ABSTRACT:
The present invention is concerned with novel anticancer agents having potent antineoplastic activity without systemic toxicity and mutagenicity. The novel anticancer agents of the present invention are derivatives of formula I: ##STR1## wherein: A is O or NH; and
B is an aryl group selected from the group consisting of phenyl, indane, fluorene, indazole, indole, and pyridine, the aryl group being substituted with at least one substituent selected from the group consisting of hydrogen, C.sub.1-16 alkyl optionally substituted with one or more OH or SH, lower alkoxy, C.sub.3-6 cycloalkyl, lower alkylthio, nitro, cyano, lower alkene, lower alkyne, OH, SH, carboxy lower alkyl, carboxy lower alkyl esters, amino, N-lower alkyl, N,N-dilower alkyl and halogen;
or a prodrug thereof, with the provisos that when A is NH and B is phenyl:
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C. -Gaudreault René
Poyet Patrick
Rotman Alan L.
Universite Laval
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