Certain aryl or hetero-hydroxamic acid esters useful as renin in

Organic compounds -- part of the class 532-570 series – Organic compounds – Hydroxamate esters or chalcogen analogues thereof

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560158, 546335, 546337, 546176, 546149, 546139, 546140, 546264, 548491, 548455, C07C12506, C07D21170, C07D21182, C07D21512

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active

047772867

ABSTRACT:
Process and compounds for producing intermediates for the production of renin inhibitors.

REFERENCES:
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patent: 4424207 (1984-01-01), Szelke
patent: 4477441 (1984-10-01), Boger
patent: 4481192 (1984-11-01), Cazaubon
Ann. Rev. Biochem., 51, pp. 283-308 (1982), M. A. Ondetti & D. W. Cushman, "Enzymes of the Renin . . . ".
J. Am. Chem. Soc., 101, p. 3983 (1979), P. G. Mattingly et al., "A Facile Synthesis of Substituted . . . ".
Journ. Org. Chem., 47, p. 5160 (1982), D. M. Floyd et al., "Monobactams. Preparation of (S)-3-Amino-2-Oxoazetidine-1-Sulfonic Acids . . . ".
Trans Biochem. Soc., 12, p. 956 (1984), D. F. Veber et al., "Renin Inhibitors . . . ".
Journ. Chem. Soc. Chem. Comm., p. 109 (1985) M. G. Bock et al., "Dipeptide Analogues. Synthesis of a Potent Renin Inhibitor".
J. Org. Chem., 45, p. 410 (1980) P. G. Mattingly et al., "Titanium Trichloride Reduction of Substituted N-Hydroxy-2-Azetidinones . . . ".

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