Certain aryl fused imidazopyrimidines; a new class of GABA brain

Details Certain aryl fused imidazopyrimidines; a new class of GABA brain Certain aryl fused imidazopyrimidines; a new class of GABA brain

1991-12-19

1993-05-18

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544115, 544250, 544279, 546289, C07D48704, C07D49514, C07D49814, C07D51314

Patent

active

052123103

ABSTRACT:
The present invention encompasses structures of the formula: ##STR1## and the pharmaceutically acceptable non-toxic salts thereof wherein: ##STR2## and W, X, A, B, C, D, E, R.sub.3, R.sub.4 are variables. These compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs thereof and are useful in the diagnosis and treatment of anxiety, sleep, and seizure disorders, overdose with benzodiazepine drugs, and enhancement of memory.

REFERENCES:
patent: 3309369 (1967-03-01), Schindler
patent: 3891638 (1975-06-01), Inaba et al.
patent: 4585772 (1986-04-01), Junge et al.
patent: 5095015 (1992-03-01), Albaugh
patent: 5128338 (1992-07-01), Bourguignon et al.
Bourguignon et al, Chemical Abstracts, vol. 116, No. 21068 (1992) (Abstract for EP 446141, Sep. 11, 1991).

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