Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1984-06-01
1986-03-25
Jiles, Henry R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546321, C07D21190, A61K 31455
Patent
active
045783950
ABSTRACT:
A 1,4-dihydropyridine derivative of the formula ##STR1## wherein R.sup.1 and R.sup.2 are identical or different and each represents a hydrogen atom, a halogen atom or a nitro group, provided that R.sup.1 and R.sup.2 are not hydrogen atoms at the same time; R.sup.3 represents an alkyl group; R.sup.4 represents an aralkyl group which may be substituted; R.sup.5 and R.sup.7 are indentical or different and each represents an alkyl group; R.sup.6 represents a hydrogen atom or an alkyl group; R.sup.8 represents an alkyl group; R.sup.9 represents a hydrogen atom or an alkyl group; n and m are identical or different and each represents an integer of 0 to 6; provided that when either one of R.sup.1 and R.sup.2 is a hydrogen atom, R.sup.9 is an alkyl group;
or an acid addition salt thereof.
The 1,4-dihydropyridine derivative is characterized by a strong antihypertensive activity and the long duration of the activity.
REFERENCES:
patent: 3985758 (1976-10-01), Murakami et al.
patent: 4264611 (1981-04-01), Berntsson et al.
Kanno Hideo
Okamiya Yoshiaki
Sunakawa Kiyotaka
Yamaguchi Hisao
Bjorkman Dale A.
Jiles Henry R.
Teijin Limited
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