Certain anti-inflammatory cyclohepta[b]pyridines and analogs the

Details Certain anti-inflammatory cyclohepta[b]pyridines and analogs the Certain anti-inflammatory cyclohepta[b]pyridines and analogs the

1989-06-16

1990-12-04

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514299, 514307, 514314, 544333, 546112, 546145, 546141, 546143, 546146, 546148, 546168, 546174, 546176, 546183, A61K 31435, C07D22104

Patent

active

049754319

ABSTRACT:
The invention concerns compounds of formula I ##STR1## or a salt thereof, wherein R.sup.1 and R.sup.2 each independently represent hydrogen, lower alkyl, lower alkoxy, carboxyloweralkyl, carboxy, hydroxyloweralkyl, halogen, haloloweralkyl, lower alkoxycarbonyl, optionally substituted aryl or optionally substituted aralkyl, n represents an integer from 3 to 6; R.sup.3 represents hydrogen or single or multiple substitution on one or more of the aliphatic carbons by one or more substituents selected from lower alkyl, optionally substituted aryl and optionally substituted aralkyl; A represents a group of formula (i) or (ii) below:

REFERENCES:
patent: 4085215 (1978-04-01), Curran et al.
patent: 4547510 (1985-10-01), Crossley
Ann. Rept. ITSUU Laboratory, 15, 1-7 (1968).
Roczniki Chemii, 43(4), 807-20 (1969).
Arch. Pharm. (Weinheim), 303, 667-675 (1970).
Arch. Pharm. (Weinheim), 314, 302-307 (1981).
J. Am. Chem., 46, 1522-1534 (1924).
The Chemistry of Heterocyclic Compounds, Pyridine and Its Derivatives, Part I, 1961; pp. 337-338.

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